Mariners vs. Tigers prediction: Seattle favored to win Game 4 of ALDS [10/8/2025]

The Detroit Tigers and Seattle Mariners will lock horns in Game 4 of the American League Division Series at Comerica Park on Wednesday, starting at 3:08PM ET.

The Tigers will send Casey Mize (0-0, 3.00 ERA in 2025 postseason) to the mound, up against Bryce Miller (0-0, 0.00 ERA) for the Mariners.

Based on updated simulation results, Dimers' proven MLB model predicts the Mariners as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Mariners-Tigers game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Mariners' chance of winning at 51%, with the Tigers at 49%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Mariners vs. Tigers predictions page.

Mariners vs. Tigers prediction: Who will win Game 4?

Using innovative machine learning and data analysis, we have simulated the result of Wednesday's MLB matchup between the Mariners and Tigers 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Mariners a 51% chance of beating the Tigers.

According to our model, the over/under total of 8 runs has a 69% chance of going over.

Mariners vs. Tigers Game 4 odds [10/8/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	Tigers
Moneyline	-108	-108
Total	o8 (-118)	u8 (-103)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. Tigers picks and best bets for Game 4

Our model's strongest edge in today's Mariners vs. Tigers matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Mariners vs. Tigers game-day updates and essential details

Wednesday's MLB matchup between the Tigers and Mariners at Comerica Park is scheduled to start at 3:08PM ET.

• Who: Seattle Mariners vs. Detroit Tigers
• Date: Wednesday, October 8, 2025
• Time: 3:08PM ET/12:08PM PT
• Venue: Comerica Park

Dimers' full preview of Wednesday's Mariners vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any Mariners vs. Tigers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Mariners, with a 51% win probability, will likely beat the Tigers on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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