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Seahawks vs. 49ers prediction: Seattle favored to win in NFL Week 18 [2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Seattle Seahawks vs San Francisco 49ers predictions for NFL Saturday.
The San Francisco 49ers will take on the Seattle Seahawks in NFL Week 18 action at Levi's Stadium on Saturday, commencing at 8:00 PM ET.
Based on the latest simulation results, Dimers' advanced NFL model projects the Seahawks as the most likely winner of the Seahawks vs. 49ers game.
This article offers an expanded analysis of Saturday's matchup, including projected touchdown scorers, best bets and player prop picks.
Seahawks vs. Niners prediction: Who will win and cover?
Since our Seahawks-49ers predictions earlier in the week, we have simulated the result of Saturday's NFL matchup between the Seahawks and 49ers 10,000 times as part of our NFL predictions coverage.
Our independent predictive model gives the Seahawks a 56% chance of beating the 49ers in Week 18 of the NFL season. Our predicted final score has the Seahawks winning 24-23.
According to our model, the 49ers (+2.5) have a 58% chance of covering the spread, while the 48.5-point over/under has a 53% chance of staying under.
To see win probabilities for every matchup this week, check out our expert NFL Week 18 straight up picks.
Seahawks vs. 49ers odds
We have researched the best NFL odds in America for this game, which are listed here:
| Bet Type | Seahawks | 49ers |
|---|---|---|
| Spread | -2.5 (-120) | +2.5 (+100) |
| Moneyline | -150 | +136 |
| Total | o48.5 (-110) | u48.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Seahawks vs. 49ers picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | 49ers +2.5 | +100 |
| Moneyline | 49ers | +136 |
| Total | Under 48.5 | -110 |
According to our NFL best bets, the top play to make on this game is 49ers +2.5 at the spread.
Seahawks vs. 49ers TD scorers
Who will score a touchdown in Seahawks vs. 49ers?
According to our list of touchdown scorer predictions for today, Christian McCaffrey is most likely to score an anytime TD in Seahawks vs. 49ers.
Our projections give McCaffrey a 59.8% chance of scoring a TD at Levi's Stadium, while the running back is a 15.8% chance of scoring the first touchdown the game.
Anytime touchdown scorer predictions
Seattle Seahawks
| Player | Anytime TD Probability |
|---|---|
| Jaxon Smith-Njigba (WR) | 46.6% |
| Zach Charbonnet (RB) | 43.4% |
| AJ Barner (TE) | 35.1% |
| Kenneth Walker (RB) | 34.8% |
| Cooper Kupp (WR) | 22.9% |
San Francisco 49ers
| Player | Anytime TD Probability |
|---|---|
| Christian McCaffrey (RB) | 59.8% |
| George Kittle (TE) | 36.0% |
| Jauan Jennings (WR) | 32.6% |
| Brock Purdy (QB) | 15.9% |
| Demarcus Robinson (WR) | 13.7% |
First touchdown scorer predictions
Seattle Seahawks
| Player | First TD Probability |
|---|---|
| Jaxon Smith-Njigba (WR) | 10.7% |
| Zach Charbonnet (RB) | 9.7% |
| AJ Barner (TE) | 7.4% |
| Kenneth Walker (RB) | 7.3% |
| Cooper Kupp (WR) | 4.4% |
San Francisco 49ers
| Player | First TD Probability |
|---|---|
| Christian McCaffrey (RB) | 15.8% |
| George Kittle (TE) | 7.8% |
| Jauan Jennings (WR) | 6.9% |
| Brock Purdy (QB) | 3.0% |
| Demarcus Robinson (WR) | 2.6% |
Seahawks vs 49ers player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Seahawks and 49ers. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 18 games.
Quarterbacks
Of the starting quarterbacks, the Seahawks' Sam Darnold is projected for 238 passing yards, while the 49ers' Brock Purdy is expected to throw for 246 yards.
| Player | Proj. Pass Yards |
|---|---|
| Sam Darnold (SEA) | 238 |
| Brock Purdy (SF) | 246 |
Seahawks rushing
| Player | Proj. Rush Yards |
|---|---|
| Kenneth Walker | 54 |
| Zach Charbonnet | 45 |
| Sam Darnold | 8 |
49ers rushing
| Player | Proj. Rush Yards |
|---|---|
| Christian McCaffrey | 70 |
| Brock Purdy | 19 |
| Brian Robinson | 18 |
Seahawks receiving
| Player | Proj. Rec. Yards |
|---|---|
| Jaxon Smith-Njigba | 101 |
| AJ Barner | 41 |
| Cooper Kupp | 39 |
| Rashid Shaheed | 35 |
| Kenneth Walker | 16 |
49ers receiving
| Player | Proj. Rec. Yards |
|---|---|
| George Kittle | 62 |
| Jauan Jennings | 49 |
| Christian McCaffrey | 46 |
| Kendrick Bourne | 32 |
| Demarcus Robinson | 23 |
Seahawks vs. Niners game-day updates and essential details
The NFL Week 18 action between the 49ers and Seahawks at Levi's Stadium is scheduled to start at 8:00 PM ET.
- Who: Seattle Seahawks vs. San Francisco 49ers
- Date: Saturday, January 3, 2026
- Time: 8:00 PM ET/5:00PM PT
- Venue: Levi's Stadium
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Conclusion
We predict the Seahawks, with a 56% win probability, will likely beat the 49ers in Week 18 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate Seahawks vs. 49ers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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