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Southern Indiana vs. South Dakota prediction: South Dakota favored to win men's college basketball matchup [11/12/2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Southern Indiana vs South Dakota predictions for college basketball Wednesday.
South Dakota and Southern Indiana will meet in men's college basketball action at Sanford Coyote Sports Center on Wednesday, starting at 8:00PM ET.
Based on updated simulations, Dimers' proven college basketball model predicts South Dakota as the most likely winner of the Southern Indiana vs. South Dakota game.
This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.
Southern Indiana vs. South Dakota prediction: Who will win, cover the spread?
Using powerful machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball matchup between Southern Indiana and South Dakota 10,000 times as part of our men's college basketball predictions coverage.
Our independent predictive model gives South Dakota a 72% chance of defeating Southern Indiana. Our predicted final score has South Dakota winning 85-78.
According to our model, Southern Indiana (+7.5) has a 55% chance of covering the spread, while the over/under total of 164.5 points has a 51% chance of staying under.
Southern Indiana vs. South Dakota odds
We have sourced the best Men's College Basketball odds in America for this game, which are listed here:
| Bet Type | Southern Indiana | South Dakota |
|---|---|---|
| Spread | +7.5 (-105) | -7.5 (-112) |
| Moneyline | +270 | -325 |
| Total | o164.5 (-105) | u164.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Southern Indiana vs. South Dakota picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Southern Indiana +7.5 | -105 |
| Moneyline | Southern Indiana | +270 |
| Total | Under 164.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is Southern Indiana +7.5 at the spread.
Southern Indiana vs. South Dakota game-day updates and essential details
Wednesday's men's college basketball matchup between South Dakota and Southern Indiana at Sanford Coyote Sports Center is scheduled to commence at 8:00PM ET.
- Who: Southern Indiana vs. South Dakota
- Date: Wednesday, November 12, 2025
- Time: 8:00PM ET/5:00PM PT
- Venue: Sanford Coyote Sports Center
Conclusion
We predict South Dakota, with a 72% win probability, will likely beat Southern Indiana on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Southern Indiana vs. South Dakota insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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