Southern Miss vs. LSU prediction: LSU favored to win men's college basketball matchup [12/29/2025]

Men's college basketball action continues on Monday at 8:00 PM ET as Southern Miss squares off with LSU in men's college basketball action at Pete Maravich Assembly Center.

Based on updated simulation results, Dimers' advanced college basketball model projects LSU as the most likely winner of the Southern Miss vs. LSU game.

This article offers a closer look at Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Miss vs. LSU prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Monday's NCAA basketball matchup between Southern Miss and LSU 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives LSU a 95% chance of defeating Southern Miss. Our predicted final score has LSU winning 87-67.

According to our model, Southern Miss (+21.5) has a 52% chance of covering the spread, while the over/under total of 155.5 points has a 52% chance of going over.

Southern Miss vs. LSU odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern Miss vs. LSU picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Southern Miss to win.

Southern Miss vs. LSU game-day updates and essential details

Monday's men's college basketball action between LSU and Southern Miss at Pete Maravich Assembly Center is scheduled to begin at 8:00 PM ET.

• Who: Southern Miss vs. LSU
• Date: Monday, December 29, 2025
• Time: 8:00 PM ET/5:00PM PT
• Venue: Pete Maravich Assembly Center

Conclusion

We predict LSU, with a 95% win probability, will likely beat Southern Miss on Monday.

AI and automation have enhanced this article to quickly deliver accurate Southern Miss vs. LSU insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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