Southern University vs. Illinois prediction: Why Illinois is favored to win men's college basketball matchup [12/29/2025]

Illinois will take on Southern University in men's college basketball action at State Farm Center on Monday, starting at 3:00 PM ET.

Based on updated simulation results, Dimers' proven college basketball model predicts Illinois as the most likely winner of the Southern University vs. Illinois game.

This article offers an expanded analysis of Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern University vs. Illinois prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the outcome of Monday's NCAA basketball game between Southern University and Illinois 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Illinois a 99% chance of beating Southern University. Our predicted final score has Illinois winning 96-65.

According to our model, Southern University (+33.5) has a 54% chance of covering the spread, while the over/under total of 163.5 points has a 52% chance of staying under.

Southern University vs. Illinois odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern University vs. Illinois picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best men's college basketball bets, the top play to make on this game is Southern University +33.5 at the spread.

Southern University vs. Illinois game-day updates and essential details

Monday's men's college basketball game between Illinois and Southern University at State Farm Center is scheduled to commence at 3:00 PM ET.

• Who: Southern University vs. Illinois
• Date: Monday, December 29, 2025
• Time: 3:00 PM ET/12:00PM PT
• Venue: State Farm Center

Conclusion

We predict Illinois, with a 99% win probability, will likely beat Southern University on Monday.

AI and automation have enhanced this article to quickly deliver accurate Southern University vs. Illinois insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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