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Cardinals vs. Marlins prediction: Why Miami is favored to win Monday's MLB matchup [4/20/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Miami Marlins predictions for MLB Monday.
The Miami Marlins will square off with the St. Louis Cardinals in MLB action at loanDepot park on Monday, starting at 6:40 PM ET.
The Marlins will have Max Meyer (1-0, 4.12 ERA) as their starting pitcher, while the Cardinals are going with Michael McGreevy (1-1, 2.49 ERA).
Based on the latest simulation results, Dimers' proven MLB model predicts the Marlins as the most likely winner of the Cardinals vs. Marlins game.
This article offers an expanded analysis of Monday's matchup, including best bets and picks.
Cardinals vs. Marlins prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the outcome of Monday's MLB matchup between the Cardinals and Marlins, forming part of our MLB predictions coverage.
Our leading predictive model gives the Marlins a 55% chance of defeating the Cardinals.
According to our model, the Cardinals (+1.5) have a 62% chance of covering the run line, while the 8.5-run over/under has a 51% chance of going over.
Cardinals vs. Marlins odds [4/20/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Marlins |
|---|---|---|
| Run Line | +1.5 (-182) | -1.5 (+155) |
| Moneyline | +116 | -134 |
| Total | o8.5 (-108) | u8.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Marlins picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Marlins -1.5 | +155 |
| Moneyline | Cardinals | +116 |
| Total | Over 8.5 | -108 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Marlins game-day updates and essential details
Monday's MLB game between the Marlins and Cardinals at loanDepot park is scheduled to begin at 6:40 PM ET.
- Who: St. Louis Cardinals vs. Miami Marlins
- Date: Monday, April 20, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: loanDepot park
Conclusion
We predict the Marlins, with a 55% win probability, will likely beat the Cardinals in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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