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Cardinals vs. Marlins prediction: Why Miami is favored to win Wednesday's MLB matchup [4/22/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Miami Marlins predictions for MLB Wednesday.
The Miami Marlins will take on the St. Louis Cardinals in MLB action at loanDepot park on Wednesday, beginning at 12:10 PM ET.
Janson Junk (0-2, 4.50 ERA) will get the ball for the Marlins, while the Cardinals will counter with Kyle Leahy (2-2, 5.21 ERA).
Based on the latest simulations, Dimers' proven MLB model predicts the Marlins as the most likely winner of the Cardinals vs. Marlins game.
This article offers further insights into Wednesday's matchup, including best bets and picks.
Cardinals vs. Marlins prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's MLB game between the Cardinals and Marlins, forming part of our MLB predictions coverage.
Our independent predictive model gives the Marlins a 59% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 59% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of staying under.
Cardinals vs. Marlins odds [4/22/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Marlins |
|---|---|---|
| Run Line | +1.5 (-166) | -1.5 (+145) |
| Moneyline | +124 | -145 |
| Total | o8.5 (-102) | u8.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Marlins picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Marlins -1.5 | +145 |
| Moneyline | Marlins | -145 |
| Total | Under 8.5 | -105 |
According to our MLB best bets, the top play to make on this game is Marlins -1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Marlins game-day updates and essential details
Wednesday's MLB action between the Marlins and Cardinals at loanDepot park is scheduled to begin at 12:10 PM ET.
- Who: St. Louis Cardinals vs. Miami Marlins
- Date: Wednesday, April 22, 2026
- Time: 12:10 PM ET/9:10AM PT
- Venue: loanDepot park
Conclusion
We predict the Marlins, with a 59% win probability, will likely beat the Cardinals in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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