Tennessee-Martin vs. Southern Illinois prediction: Southern Illinois favored to win men's college basketball matchup [12/10/2025]

Southern Illinois will take on Tennessee-Martin in men's college basketball action at Banterra Center on Wednesday, beginning at 8:00PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts Southern Illinois as the most likely winner of the Tennessee-Martin vs. Southern Illinois game.

This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Tennessee-Martin vs. Southern Illinois prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball matchup between Tennessee-Martin and Southern Illinois 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Southern Illinois an 80% chance of beating Tennessee-Martin. Our predicted final score has Southern Illinois winning 77-68.

According to our model, Southern Illinois (-8.5) has a 51% chance of covering the spread, while the 146.5-point over/under has an equal 50-50 chance of hitting.

Tennessee-Martin vs. Southern Illinois odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Tennessee-Martin vs. Southern Illinois picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Southern Illinois -8.5 at the spread.

Tennessee-Martin vs. Southern Illinois game-day updates and essential details

Wednesday's men's college basketball action between Southern Illinois and Tennessee-Martin at Banterra Center is scheduled to commence at 8:00PM ET.

• Who: Tennessee-Martin vs. Southern Illinois
• Date: Wednesday, December 10, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Banterra Center

Conclusion

We predict Southern Illinois, with an 80% win probability, will likely beat Tennessee-Martin on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Tennessee-Martin vs. Southern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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