Titans vs. Cardinals prediction: Why Arizona is favored to win in NFL Week 5, 2025

The Arizona Cardinals will take on the Tennessee Titans in NFL Week 5 action at State Farm Stadium on Sunday, starting at 4:05PM ET.

Based on the latest simulation results, Dimers' advanced NFL model projects the Cardinals as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Titans-Cardinals game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cardinals with a win probability of 77%, while the Titans have 23%."

This gameday Titans vs. Cardinals betting preview builds on my Titans vs. Cardinals prediction that was published earlier in the week.

For further insights into today’s game, including the predicted score, best bets and player prop picks, visit our interactive Titans vs. Cardinals predictions page.

Titans vs. Cardinals Predictions

Since our Titans-Cardinals predictions earlier in the week, we have simulated the result of Sunday's NFL matchup between the Titans and Cardinals 10,000 times as part of our NFL predictions coverage.

Our famous predictive model currently gives the Cardinals a 77% chance of beating the Titans in Week 5 of the NFL season. Our predicted final score has the Cardinals winning 24-17.

According to our model, the Titans (+7.5) have a 56% chance of covering the spread, while the over/under total of 41.5 points has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 5 straight up picks.

Titans vs. Cardinals odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Titans	Cardinals
Spread	+7.5 (-108)	-7.5 (-105)
Moneyline	+330	-400
Total	o41.5 (-102)	u41.5 (-108)

All odds are correct at the time of publication and are subject to change.

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Titans vs. Cardinals picks and best bets

Our model's biggest edge in today's Titans vs. Cardinals matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Titans vs. Cardinals TD scorers

Who will score the first touchdown in Titans vs. Cardinals?

According to our list of touchdown scorer predictions for today, Arizona's Michael Carter is most likely to score the first touchdown in Titans vs. Cardinals.

Our projections give Carter a 9.6% chance of scoring the first TD at State Farm Stadium, while the Cardinals running back is a 35.0% chance of scoring an anytime touchdown.

First touchdown scorer predictions

Tennessee Titans

Player	First TD Probability
Tony Pollard (RB)	9.1%
Elic Ayomanor (WR)	6.3%
Tyjae Spears (RB)	5.3%

Arizona Cardinals

Player	First TD Probability
Michael Carter (RB)	9.6%
Marvin Harrison (WR)	9.2%
Trey McBride (TE)	9.0%

Anytime touchdown scorer predictions

Tennessee Titans

Player	Anytime TD Probability
Tony Pollard (RB)	33.1%
Elic Ayomanor (WR)	24.2%
Tyjae Spears (RB)	20.7%

Arizona Cardinals

Player	Anytime TD Probability
Michael Carter (RB)	35.0%
Marvin Harrison (WR)	33.6%
Trey McBride (TE)	32.9%

Titans vs Cardinals player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Titans and Cardinals. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our NFL player projections page now to access player prop projections for every offensive player in this matchup and all other Week 5 games.

Titans vs. Cardinals quarterbacks

Of the starting quarterbacks, the Titans' Cam Ward is projected to throw for fewer yards than the Cardinals' Kyler Murray.

Titans rushing

Tony Pollard, Tyjae Spears and Cam Ward are projected to be the leading rushers for the Titans.

Player	Position
Tony Pollard	RB
Tyjae Spears	RB
Cam Ward	QB

Cardinals rushing

Michael Carter, Kyler Murray and Emari Demercado are expected to lead the Cardinals in rushing yards.

Player	Position
Michael Carter	RB
Kyler Murray	QB
Emari Demercado	RB

Titans receiving

Elic Ayomanor, Calvin Ridley, Chig Okonkwo, Tyler Lockett and Gunnar Helm are projected to top the receiving yards for the Titans.

Player	Position
Elic Ayomanor	WR
Calvin Ridley	WR
Chig Okonkwo	TE
Tyler Lockett	WR
Gunnar Helm	TE

Cardinals receiving

Trey McBride, Marvin Harrison, Michael Wilson, Zay Jones and Emari Demercado are projected to lead the Cardinals in receiving yards.

Player	Position
Trey McBride	TE
Marvin Harrison	WR
Michael Wilson	WR
Zay Jones	WR
Emari Demercado	RB

Titans vs. Cardinals game-day updates and essential details

The NFL Week 5 matchup between the Cardinals and Titans at State Farm Stadium is scheduled to begin at 4:05PM ET.

• Who: Tennessee Titans vs. Arizona Cardinals
• Date: Sunday, October 5, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: State Farm Stadium

Dimers' full preview of this week's Titans vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Titans vs. Cardinals picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 77% win probability, will likely beat the Titans in Week 5 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Titans vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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