Wyoming vs. South Dakota State prediction: Wyoming favored to win men's college basketball matchup [12/15/2025]

South Dakota State and Wyoming are scheduled to meet in men's college basketball action at Sanford Pentagon on Monday, starting at 8:00PM ET.

Based on updated simulations, Dimers' proven college basketball model predicts Wyoming as the most likely winner of the Wyoming vs. South Dakota State game.

This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Wyoming vs. South Dakota State prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Monday's NCAA basketball game between Wyoming and South Dakota State 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Wyoming a 61% chance of beating South Dakota State. Our predicted final score has Wyoming winning 76-73.

According to our model, South Dakota State (+3.5) has a 56% chance of covering the spread, while the 149.5-point over/under has a 52% chance of going over.

Wyoming vs. South Dakota State odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Wyoming vs. South Dakota State picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: