Jun 22, 2026
Brewers vs. Reds prediction: Why Milwaukee is favored to win Monday's MLB matchup [6/22/2026]
Read Article Diamondbacks vs. Cardinals prediction: St. Louis favored to win Monday's MLB matchup [6/22/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Arizona Diamondbacks vs St. Louis Cardinals predictions for MLB Monday.
The St. Louis Cardinals will take on the Arizona Diamondbacks, in what is expected to be a tight MLB game, at Busch Stadium on Monday, starting at 7:45 PM ET.
Andre Pallante (8-4, 3.76 ERA) will start on the mound for the Cardinals, up against Merrill Kelly (5-6, 5.81 ERA) for the Diamondbacks.
Based on the latest simulations, Dimers' proven MLB model gives the Cardinals a slight edge with a 54.2% win probability over the Diamondbacks.
This article offers further insights into Monday's Diamondbacks vs. Cardinals matchup, including best bets and picks.
Diamondbacks vs. Cardinals prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the outcome of Monday's MLB matchup between the Diamondbacks and Cardinals, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Cardinals a 54.2% chance of beating the Diamondbacks.
According to our model, the Diamondbacks (+1.5) have a 63.1% chance of covering the run line, while the over/under total of 8.5 runs has a 53.5% chance of going over,.
Diamondbacks vs. Cardinals odds [6/22/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Diamondbacks | Cardinals |
|---|---|---|
| Run Line | +1.5 (-174) | -1.5 (+146) |
| Moneyline | +120 | -142 |
| Total | o8.5 (-110) | u8.5 (-106) |
All odds are correct at the time of publication and are subject to change.
Diamondbacks vs. Cardinals picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Diamondbacks +1.5 | -174 |
| Moneyline | Diamondbacks | +120 |
| Total | Over 8.5 | -110 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Diamondbacks vs. Cardinals game-day updates and essential details
Monday's MLB action between the Cardinals and Diamondbacks at Busch Stadium is scheduled to commence at 7:45 PM ET.
- Who: Arizona Diamondbacks vs. St. Louis Cardinals
- Date: Monday, June 22, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict the Cardinals, with a 54.2% win probability, will likely beat the Diamondbacks in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
Advertiser disclosure
