Bulls vs. 76ers prediction: Why Philadelphia is favored to win Wednesday's NBA matchup [3/25/2026]

The Philadelphia 76ers and Chicago Bulls will lock horns in NBA action at Xfinity Mobile Arena on Wednesday, starting at 7:00 PM ET.

Based on updated simulations and today’s injury reports, Dimers' advanced NBA model predicts the 76ers as the most likely winner of the Bulls vs. 76ers game.

This prediction follows the latest NBA Injury Report, which suggests the 76ers lineup will feature players like Joel Embiid, VJ Edgecombe and Paul George, while the Bulls will look to Matas Buzelis, Josh Giddey and Tre Jones.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Sixers vs. Sixers prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Wednesday's NBA matchup between the Bulls and 76ers, forming part of our NBA predictions coverage.

Our leading predictive model currently gives the 76ers a 70% chance of defeating the Bulls. Our predicted final score has the 76ers winning 122-116.

According to our model, the Bulls (+6.5) have a 52% chance of covering the spread, while the 241.5-point over/under has a 54% chance of staying under.

Bulls vs. 76ers odds

We have sourced the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Bulls vs. 76ers picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Wednesday, the top play to make on this game is Under 241.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Bulls vs. 76ers player props

Betting on Bulls vs. 76ers NBA prop bets? We use the best information available to project how each team's leading players will perform at Xfinity Mobile Arena.

Matas Buzelis is expected to lead the Bulls with 20 points, 6 rebounds and 3 assists, while Joel Embiid is projected to have 23 points, 6 rebounds and 4 assists for the 76ers.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.

Bulls prediction

Our model's projected player stats for the Bulls are:

76ers prediction

Projected points, rebounds, assists and three-pointers made for the 76ers:

Bulls vs. Sixers game-day updates and essential details

Wednesday's action between the 76ers and Bulls at Xfinity Mobile Arena is scheduled to begin at 7:00 PM ET.

• Who: Chicago Bulls vs. Philadelphia 76ers
• Date: Wednesday, March 25, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Xfinity Mobile Arena

Conclusion

We predict the 76ers, with a 70% win probability, will likely beat the Bulls on Wednesday, with Josh Giddey projected for a game-high 52 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Bulls vs. 76ers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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