May 20, 2026
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Read Article Cubs vs. White Sox prediction: Why Cubs are favored to win Saturday's MLB matchup [5/16/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Chicago Cubs vs Chicago White Sox predictions for MLB Saturday.
The Chicago White Sox will square off with the Chicago Cubs, in what is expected to be a tight MLB game, at Rate Field on Saturday, commencing at 7:10 PM ET.
Davis Martin (5-1, 1.62 ERA) will start for the White Sox, while the Cubs will counter with Jameson Taillon (2-2, 3.94 ERA).
Based on the latest simulations, Dimers' proven MLB model gives the Cubs a slight edge with a 51% win probability over the White Sox.
This article offers further insights into Saturday's Cubs vs. White Sox matchup, including best bets and picks.
Cubs vs. White Sox prediction: Who will win?
Using powerful machine learning and data, we have simulated the result of Saturday's MLB game between the Cubs and White Sox, forming part of our MLB predictions coverage.
Our famous predictive model gives the Cubs a 51% chance of defeating the White Sox.
According to our model, the 8.5-run over/under has a 54% chance of going over.
Cubs vs. White Sox odds [5/16/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Cubs | White Sox |
|---|---|---|
| Moneyline | -108 | -107 |
| Total | o8.5 (-110) | u8.5 (-107) |
All odds are correct at the time of publication and are subject to change.
Cubs vs. White Sox picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Moneyline | Cubs | -108 |
| Total | Over 8.5 | -110 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. White Sox game-day updates and essential details
Saturday's MLB action between the White Sox and Cubs at Rate Field is scheduled to begin at 7:10 PM ET.
- Who: Chicago Cubs vs. Chicago White Sox
- Date: Saturday, May 16, 2026
- Time: 7:10 PM ET/4:10PM PT
- Venue: Rate Field
Conclusion
We predict the Cubs, with a 51% win probability, will likely beat the White Sox in Saturday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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