May 25, 2026
Nationals vs. Guardians prediction: Why Cleveland is favored to win Monday's MLB matchup [5/25/2026]
Read Article Cubs vs. Pirates prediction: Why Cubs are favored to win Monday's MLB matchup [5/25/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Chicago Cubs vs Pittsburgh Pirates predictions for MLB Monday.
MLB action continues on Monday at 1:35 PM ET as the Chicago Cubs take on the Pittsburgh Pirates at PNC Park.
The Pirates will send Carmen Mlodzinski (4-3, 3.96 ERA) to the mound, while the Cubs have opted for Ben Brown (1-2, 2.10 ERA).
Based on updated simulations, Dimers' proven MLB model gives the Cubs a slight edge with a 54% win probability over the Pirates.
This article offers further insights into Monday's Cubs vs. Pirates matchup, including best bets and picks.
Cubs vs. Pirates prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the result of Monday's MLB matchup between the Cubs and Pirates, forming part of our MLB predictions coverage.
Our famous predictive model gives the Cubs a 54% chance of defeating the Pirates.
According to our model, the Pirates (+1.5) have a 59% chance of covering the run line, while the over/under total of eight runs has a 55% chance of going over.
Cubs vs. Pirates odds [5/25/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Cubs | Pirates |
|---|---|---|
| Run Line | -1.5 (+135) | +1.5 (-162) |
| Moneyline | -124 | +106 |
| Total | o8 (-115) | u8 (-105) |
All odds are correct at the time of publication and are subject to change.
Cubs vs. Pirates picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cubs -1.5 | +135 |
| Moneyline | Cubs | -124 |
| Total | Over 8 | -115 |
According to our MLB best bets, the top play to make on this game is Over 8 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. Pirates game-day updates and essential details
Monday's MLB game between the Pirates and Cubs at PNC Park is scheduled to commence at 1:35 PM ET.
- Who: Chicago Cubs vs. Pittsburgh Pirates
- Date: Monday, May 25, 2026
- Time: 1:35 PM ET/10:35AM PT
- Venue: PNC Park
Conclusion
We predict the Cubs, with a 54% win probability, will likely beat the Pirates in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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