White Sox vs. Nationals prediction: Why Washington is favored to win Saturday's MLB matchup [9/27/2025]

The Washington Nationals will square off with the Chicago White Sox in MLB action at Nationals Park on Saturday, starting at 4:05PM ET.

The Nationals will have Jake Irvin (9-13, 5.69 ERA) as their starting pitcher, up against Sean Burke (4-11, 4.29 ERA) for the White Sox.

Based on the latest simulations, Dimers' proven MLB model predicts the Nationals as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive White Sox vs. Nationals predictions page.

Nationals vs. White Sox prediction: Who will win?

Using trusted machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the White Sox and Nationals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Nationals a 51% chance of beating the White Sox.

According to our model, the 8.5-run over/under has a 59% chance of going over.

White Sox vs. Nationals odds [9/27/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Nationals
Moneyline	-104	-110
Total	o8.5 (-115)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Nationals picks and best bets

Our model's biggest edge in today's White Sox vs. Nationals matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

White Sox vs. Nationals game-day updates and essential details

Saturday's MLB game between the Nationals and White Sox at Nationals Park is scheduled to commence at 4:05PM ET.

• Who: Chicago White Sox vs. Washington Nationals
• Date: Saturday, September 27, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Nationals Park

Dimers' full preview of Saturday's White Sox vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any White Sox vs. Nationals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Nationals, with a 51% win probability, will likely beat the White Sox on Saturday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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