Cavaliers vs. Bulls prediction: Cleveland to win, Donovan Mitchell projected for big game in Wednesday's NBA matchup [12/17/2025]

NBA action continues on Wednesday at 8:00 PM ET as the Cleveland Cavaliers take on the Chicago Bulls at United Center.

Based on the latest simulations and today’s injury news, Dimers' proven NBA model projects the Cavaliers as the most likely winner of the Cavaliers vs. Bulls game.

This prediction follows the latest NBA Injury Report, which suggests the Bulls lineup will feature stars like Coby White, Josh Giddey and Nikola Vucevic, while the Cavaliers will rely on Donovan Mitchell, Darius Garland and De'Andre Hunter.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Cavs vs. Bulls prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's NBA game between the Cavaliers and Bulls 10,000 times as part of our NBA predictions coverage.

Our independent predictive model gives the Cavaliers a 66% chance of beating the Bulls. Our predicted final score has the Cavaliers winning 122-118.

According to our model, the Bulls (+5.5) have a 53% chance of covering the spread, while the over/under total of 243.5 points has a 54% chance of staying under.

Cavaliers vs. Bulls odds

We have sourced the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Cavaliers vs. Bulls picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Wednesday, the top play to make on this game is Under 243.5 total points.

Cavaliers vs. Bulls player props

NBA player props are an enjoyable way to wager on Wednesday's Cleveland vs. Chicago game without necessarily betting on the outcome. We use the best information available to project how each team's leading players will perform at United Center.

Donovan Mitchell is expected to lead the Cavaliers with 30 points, 5 rebounds and 6 assists, while Coby White is projected to have 20 points, 3 rebounds and 4 assists for the Bulls.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.

Cavaliers prediction

Our model's projected player stats for the Cavaliers are:

Bulls prediction

Projected points, rebounds, assists and three-pointers made for the Bulls:

Cavs vs. Bulls game-day updates and essential details

Wednesday's action between the Bulls and Cavaliers at United Center is scheduled to begin at 8:00 PM ET.

• Who: Cleveland Cavaliers vs. Chicago Bulls
• Date: Wednesday, December 17, 2025
• Time: 8:00 PM ET/5:00PM PT
• Venue: United Center

Conclusion

We predict the Cavaliers, with a 66% win probability, will likely beat the Bulls on Wednesday, with Donovan Mitchell projected for a game-high 52 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Cavaliers vs. Bulls insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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