Cavaliers vs. Spurs prediction: San Antonio to win, Donovan Mitchell projected for 27 points in Monday's NBA game [12/29/2025]

The San Antonio Spurs and Cleveland Cavaliers are scheduled to meet in NBA action at Frost Bank Center on Monday, with tipoff at 8:00 PM ET.

Based on the latest simulation results and today’s injury news, Dimers' proven NBA model predicts the Spurs as the most likely winner of the Cavaliers vs. Spurs game.

This prediction follows the latest NBA Injury Report, which suggests the Spurs lineup will feature players like Victor Wembanyama, De'Aaron Fox and Stephon Castle, while the Cavaliers will rely on Donovan Mitchell, Darius Garland and Evan Mobley.

This article offers an expanded analysis of Monday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Cavs vs. Spurs prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Monday's NBA game between the Cavaliers and Spurs 10,000 times as part of our NBA predictions coverage.

Our famous predictive model gives the Spurs a 62% chance of beating the Cavaliers. Our predicted final score has the Spurs winning 122-119.

According to our model, the bookmakers have got it right, and the Cavaliers and Spurs each have a 50% chance of covering the spread, while the 243.5-point over/under has a 54% chance of staying under.

Cavaliers vs. Spurs odds

We have sourced the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Cavaliers vs. Spurs picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Monday, the top play to make on this game is Under 243.5 total points.

Cavaliers vs. Spurs player props

NBA prop bets are a popular way to wager on Monday's Cavaliers vs. Spurs game without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at Frost Bank Center.

Donovan Mitchell is expected to lead the Cavaliers with 27 points, 5 rebounds and 6 assists, while Victor Wembanyama is projected to have 23 points, 11 rebounds and 4 assists for the Spurs.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.

Cavaliers prediction

Our model's projected player stats for the Cavaliers are:

Spurs prediction

Projected points, rebounds, assists and three-pointers made for the Spurs:

Cavs vs. Spurs game-day updates and essential details

Monday's game between the Spurs and Cavaliers at Frost Bank Center is scheduled to start at 8:00 PM ET.

• Who: Cleveland Cavaliers vs. San Antonio Spurs
• Date: Monday, December 29, 2025
• Time: 8:00 PM ET/5:00PM PT
• Venue: Frost Bank Center

Conclusion

We predict the Spurs, with a 62% win probability, will likely beat the Cavaliers on Monday, with Victor Wembanyama projected for a game-high 52 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Cavaliers vs. Spurs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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