...
...
Read Article
Astros vs. Reds prediction: Why Cincinnati is favored to win Friday's MLB matchup [5/8/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Houston Astros vs Cincinnati Reds predictions for MLB Friday.
The Cincinnati Reds and Houston Astros will lock horns in MLB action at Great American Ball Park on Friday, starting at 6:10 PM ET.
Nick Lodolo (0-0, 0.00 ERA) will be the starting pitcher for the Reds, while the Astros are going with Mike Burrows (1-4, 5.97 ERA).
Based on the latest simulation results, Dimers' advanced MLB model gives the Reds a slight edge with a 53% win probability over the Astros.
This article offers a closer look at Friday's Astros vs. Reds matchup, including best bets and picks.
Astros vs. Reds prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the outcome of Friday's MLB game between the Astros and Reds, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Reds a 53% chance of defeating the Astros.
According to our model, the Astros (+1.5) have a 62% chance of covering the run line, while the over/under total of nine runs has a 56% chance of going over.
Astros vs. Reds odds [5/8/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Astros | Reds |
|---|---|---|
| Run Line | +1.5 (-171) | -1.5 (+154) |
| Moneyline | +115 | -134 |
| Total | o9 (-118) | u9 (-102) |
All odds are correct at the time of publication and are subject to change.
Astros vs. Reds picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Astros +1.5 | -171 |
| Moneyline | Astros | +115 |
| Total | Over 9 | -118 |
According to our MLB best bets, the top play to make on this game is Over 9 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Astros vs. Reds game-day updates and essential details
Friday's MLB action between the Reds and Astros at Great American Ball Park is scheduled to start at 6:10 PM ET.
- Who: Houston Astros vs. Cincinnati Reds
- Date: Friday, May 8, 2026
- Time: 6:10 PM ET/3:10PM PT
- Venue: Great American Ball Park
Conclusion
We predict the Reds, with a 53% win probability, will likely beat the Astros in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Continue reading with Dimers Pro
Join now to unlock this article and get full access to our predictions and betting tools. Cancel anytime.
$0 for 3 days
then $14.99/week
Already a Pro member? Log in
New here? See everything Pro includes
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
Advertiser disclosure