May 20, 2026
Pirates vs. Cardinals prediction: St. Louis favored to win Wednesday's MLB matchup [5/20/2026]
Read Article Astros vs. Twins prediction: Why Minnesota is favored to win Wednesday's MLB matchup [5/20/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Houston Astros vs Minnesota Twins predictions for MLB Wednesday.
The Minnesota Twins and Houston Astros are scheduled to meet in MLB action at Target Field on Wednesday, starting at 1:40 PM ET.
The Twins will send Joe Ryan (2-3, 3.20 ERA) to the mound, while the Astros will counter with Mike Burrows (2-5, 5.72 ERA).
Based on the latest simulation results, Dimers' proven MLB model projects the Twins as the most likely winner of the Astros vs. Twins game.
This article offers an expanded analysis of Wednesday's matchup, including best bets and picks.
Astros vs. Twins prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the result of Wednesday's MLB matchup between the Astros and Twins, forming part of our MLB predictions coverage.
Our leading predictive model gives the Twins a 55% chance of defeating the Astros.
According to our model, the Astros (+1.5) have a 61% chance of covering the run line, while the over/under total of 7.5 runs has a 56% chance of going over.
Astros vs. Twins odds [5/20/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Astros | Twins |
|---|---|---|
| Run Line | +1.5 (-179) | -1.5 (+150) |
| Moneyline | +116 | -136 |
| Total | o7.5 (-115) | u7.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Astros vs. Twins picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Twins -1.5 | +150 |
| Moneyline | Astros | +116 |
| Total | Over 7.5 | -115 |
According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Astros vs. Twins game-day updates and essential details
Wednesday's MLB matchup between the Twins and Astros at Target Field is scheduled to commence at 1:40 PM ET.
- Who: Houston Astros vs. Minnesota Twins
- Date: Wednesday, May 20, 2026
- Time: 1:40 PM ET/10:40AM PT
- Venue: Target Field
Conclusion
We predict the Twins, with a 55% win probability, will likely beat the Astros in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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