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Read Article Dodgers vs. Padres prediction: Dodgers favored to win Wednesday's MLB matchup [5/20/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Los Angeles Dodgers vs San Diego Padres predictions for MLB Wednesday.
The San Diego Padres will square off with the Los Angeles Dodgers in MLB action at Petco Park on Wednesday, starting at 8:40 PM ET.
Randy Vásquez (5-1, 2.68 ERA) will be the starting pitcher for the Padres, up against Shohei Ohtani (3-2, 0.82 ERA) for the Dodgers.
Based on the latest simulations, Dimers' proven MLB model predicts the Dodgers as the most likely winner of the Dodgers vs. Padres game.
This article offers further insights into Wednesday's matchup, including best bets and picks.
Dodgers vs. Padres prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the outcome of Wednesday's MLB game between the Dodgers and Padres, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Dodgers a 64% chance of beating the Padres.
According to our model, the bookmakers have got it right, and the Dodgers and Padres each have a 50% chance of covering the run line, while the 7.5-run over/under has a 54% chance of going over.
Dodgers vs. Padres odds [5/20/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Dodgers | Padres |
|---|---|---|
| Run Line | -1.5 (-110) | +1.5 (-105) |
| Moneyline | -196 | +170 |
| Total | o7.5 (+104) | u7.5 (-120) |
All odds are correct at the time of publication and are subject to change.
Dodgers vs. Padres picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Padres +1.5 | -105 |
| Moneyline | Padres | +170 |
| Total | Over 7.5 | +104 |
According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Dodgers vs. Padres game-day updates and essential details
Wednesday's MLB matchup between the Padres and Dodgers at Petco Park is scheduled to begin at 8:40 PM ET.
- Who: Los Angeles Dodgers vs. San Diego Padres
- Date: Wednesday, May 20, 2026
- Time: 8:40 PM ET/5:40PM PT
- Venue: Petco Park
Conclusion
We predict the Dodgers, with a 64% win probability, will likely beat the Padres in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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