Lakers vs. Spurs prediction: San Antonio to win, Luka Doncic projected for 36 points in Wednesday's NBA game [1/7/2026]

The San Antonio Spurs and Los Angeles Lakers will lock horns in NBA action at Frost Bank Center on Wednesday, starting at 9:30 PM ET.

Based on the latest simulation results and today’s injury news, Dimers' proven NBA model predicts the Spurs as the most likely winner of the Lakers vs. Spurs game.

This prediction follows the latest NBA Injury Report, which suggests the Spurs lineup will feature players like De'Aaron Fox, Stephon Castle and Victor Wembanyama, while the Lakers will look to Luka Doncic, Deandre Ayton and Jake LaRavia.

LeBron James will miss the game though with the superstar out for this one.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Lakers vs. Spurs prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's NBA game between the Lakers and Spurs 10,000 times as part of our NBA predictions coverage.

Our leading predictive model gives the Spurs a 74% chance of beating the Lakers. Our predicted final score has the Spurs winning 120-112.

According to our model, the Lakers (+8.5) have a 54% chance of covering the spread, while the 233.5-point over/under has a 51% chance of staying under.

Lakers vs. Spurs odds

We have sourced the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Lakers vs. Spurs picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Wednesday, the top play to make on this game is Lakers +8.5 at the spread.

Lakers vs. Spurs player props

NBA player props are a popular way to wager on the LA Lakers vs. San Antonio matchup without necessarily betting on the outcome. We use the best information available to project how each team's leading players will perform at Frost Bank Center.

Luka Doncic is expected to lead the Lakers with 36 points, 8 rebounds and 9 assists, while De'Aaron Fox is projected to have 20 points, 4 rebounds and 6 assists for the Spurs.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.

Lakers prediction

Our model's projected player stats for the Lakers are:

Spurs prediction

Projected points, rebounds, assists and three-pointers made for the Spurs:

Lakers vs. Spurs game-day updates and essential details

Wednesday's action between the Spurs and Lakers at Frost Bank Center is scheduled to begin at 9:30 PM ET.

• Who: Los Angeles Lakers vs. San Antonio Spurs
• Date: Wednesday, January 7, 2026
• Time: 9:30 PM ET/6:30PM PT
• Venue: Frost Bank Center

Conclusion

We predict the Spurs, with a 74% win probability, will likely beat the Lakers on Wednesday, with Luka Doncic projected for a game-high 67 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Lakers vs. Spurs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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