Grizzlies vs. Timberwolves prediction: Why Minnesota is favored to win Wednesday's NBA matchup [12/17/2025]

The Minnesota Timberwolves will face the Memphis Grizzlies in NBA action at Target Center on Wednesday, starting at 8:00 PM ET.

Based on the latest simulation results and today’s injury updates, Dimers' proven NBA model predicts the Timberwolves as the most likely winner of the Grizzlies vs. Timberwolves game.

This prediction follows the latest NBA Injury Report, which suggests the Timberwolves lineup will feature players like Julius Randle, Bones Hyland and Jaden McDaniels, while the Grizzlies will rely on Jaren Jackson, Santi Aldama and Jaylen Wells.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Grizzlies vs. Wolves prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's NBA matchup between the Grizzlies and Timberwolves 10,000 times as part of our NBA predictions coverage.

Our independent predictive model gives the Timberwolves a 70% chance of defeating the Grizzlies. Our predicted final score has the Timberwolves winning 116-110.

According to our model, the Grizzlies (+6.5) have a 53% chance of covering the spread, while the 227.5-point over/under has a 51% chance of going over.

Grizzlies vs. Timberwolves odds

We have researched the best NBA odds in America for this game, which are listed here:

Bet Type	Grizzlies	Timberwolves
Spread	+6.5 (-108)	-6.5 (-110)
Moneyline	+220	-255
Total	o227.5 (-110)	u227.5 (-105)

All odds are correct at the time of publication and are subject to change.

Grizzlies vs. Timberwolves picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Grizzlies +6.5	-108
Moneyline	Grizzlies	+220
Total	Over 227.5	-110

According to our best NBA bets for Wednesday, the top play to make on this game is Grizzlies +6.5 at the spread.

Grizzlies vs. Timberwolves player props

Looking for Grizzlies vs. Timberwolves NBA player props? We have crunched the numbers to project how each team's leading players will perform at Target Center.

Jaren Jackson is expected to lead the Grizzlies with 19 points, 5 rebounds and 2 assists, while Julius Randle is projected to have 24 points, 7 rebounds and 5 assists for the Timberwolves.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.

Grizzlies prediction

Our model's projected player stats for the Grizzlies are:

Player	PTS	REB	AST	3PM	DFS
Jaren Jackson	19	5	2	2	34
Santi Aldama	15	7	4	2	34
Jaylen Wells	14	4	2	2	27
Cedric Coward	14	6	3	2	30
Jock Landale	11	6	2	1	25

Timberwolves prediction

Projected points, rebounds, assists and three-pointers made for the Timberwolves:

Player	PTS	REB	AST	3PM	DFS
Julius Randle	24	7	5	2	46
Bones Hyland	18	4	5	4	39
Jaden McDaniels	18	5	3	2	34
D. DiVincenzo	14	4	5	3	33
Naz Reid	14	6	3	2	33

Grizzlies vs. Wolves game-day updates and essential details

Wednesday's action between the Timberwolves and Grizzlies at Target Center is scheduled to commence at 8:00 PM ET.

• Who: Memphis Grizzlies vs. Minnesota Timberwolves
• Date: Wednesday, December 17, 2025
• Time: 8:00 PM ET/5:00PM PT
• Venue: Target Center

Conclusion

We predict the Timberwolves, with a 70% win probability, will likely beat the Grizzlies on Wednesday, with Julius Randle projected for a game-high 46 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Grizzlies vs. Timberwolves insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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