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Read Article Brewers vs. Cubs prediction: Why Cubs are favored to win Wednesday's MLB matchup [5/20/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Milwaukee Brewers vs Chicago Cubs predictions for MLB Wednesday.
The Chicago Cubs will face the Milwaukee Brewers, in what is expected to be a close MLB game, at Wrigley Field on Wednesday, starting at 7:40 PM ET.
Edward Cabrera (3-1, 4.06 ERA) will be on the bump for the Cubs, up against Kyle Harrison (4-1, 2.10 ERA) for the Brewers.
Based on the latest simulations, Dimers' proven MLB model gives the Cubs a slight edge with a 53% win probability over the Brewers.
This article offers a closer look at Wednesday's Brewers vs. Cubs matchup, including best bets and picks.
Brewers vs. Cubs prediction: Who will win?
Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Brewers and Cubs, forming part of our MLB predictions coverage.
Our independent predictive model gives the Cubs a 53% chance of beating the Brewers.
According to our model, the over/under total of 6.5 runs has a 55% chance of going over.
Brewers vs. Cubs odds [5/20/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Brewers | Cubs |
|---|---|---|
| Moneyline | +104 | -115 |
| Total | o6.5 (-105) | u6.5 (-114) |
All odds are correct at the time of publication and are subject to change.
Brewers vs. Cubs picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Moneyline | Cubs | -115 |
| Total | Over 6.5 | -105 |
According to our MLB best bets, the top play to make on this game is Over 6.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Brewers vs. Cubs game-day updates and essential details
Wednesday's MLB game between the Cubs and Brewers at Wrigley Field is scheduled to begin at 7:40 PM ET.
- Who: Milwaukee Brewers vs. Chicago Cubs
- Date: Wednesday, May 20, 2026
- Time: 7:40 PM ET/4:40PM PT
- Venue: Wrigley Field
Conclusion
We predict the Cubs, with a 53% win probability, will likely beat the Brewers in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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