MLB picks today: Saturday's MLB best bets include Padres vs. Diamondbacks play [4/25/2026]

Today’s MLB picks for April 25, 2026 are here, with Padres vs. Diamondbacks and Athletics vs. Rangers among the top plays identified by our model across Saturday’s MLB action.

Dimers’ predictive analytics engine runs 24/7, searching the latest baseball odds to find genuine betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of MLB best bets tonight [4/25, updated 7:02PM ET]

Below, you’ll find today’s top 10 baseball bets, ranked by edge for Saturday, April 25, 2026.

Padres vs. Diamondbacks under 15.5 runs (-105)

• Edge: 8.5%
• Probability: 59.7%
• Matchup: Padres vs. Diamondbacks (4:05PM ET, Sunday)

Our model has identified value on under 15.5 runs in Padres vs. Diamondbacks at -105 odds. A 59.7% probability produces an edge of 8.5%, making this the strongest play for today's MLB slate.

Athletics -1.5 (+164)

• Edge: 7.2%
• Probability: 45.1%
• Matchup: Athletics vs. Rangers (2:35PM ET, Sunday)

Athletics -1.5 carries a 7.2% edge and a probability of 45.1% at +164 odds, according to our model.

Athletics vs. Rangers over 8 runs (-110)

• Edge: 6.5%
• Probability: 58.9%
• Matchup: Athletics vs. Rangers (7:05PM ET, Saturday)

Athletics vs. Rangers over 8 runs at -110 odds shows a 6.5% edge, supported by a 58.9% probability in simulations.

Red Sox vs. Orioles over 7.5 runs (-105)

• Edge: 4.3%
• Probability: 55.5%
• Matchup: Red Sox vs. Orioles (1:35PM ET, Sunday)

A 4.3% edge and 55.5% probability make Red Sox vs. Orioles over 7.5 runs at a value play in the Red Sox vs. Orioles matchup, per our model.

Athletics vs. Rangers over 8.5 runs (-112)

• Edge: 3.7%
• Probability: 56.5%
• Matchup: Athletics vs. Rangers (2:35PM ET, Sunday)

Athletics vs. Rangers over 8.5 runs at -112 odds presents a 3.7% edge, with simulations resulting in a probability of 56.5%.

Guardians vs. Blue Jays over 8 runs (-105)

• Edge: 3.6%
• Probability: 54.8%
• Matchup: Guardians vs. Blue Jays (1:37PM ET, Sunday)

Our model finds value on over 8 runs in Guardians vs. Blue Jays at -105 odds, supported by an edge of 3.6%.

Royals -1.5 (+149)

• Edge: 3.3%
• Probability: 43.4%
• Matchup: Angels vs. Royals (7:10PM ET, Saturday)

Our model has uncovered value on Royals -1.5 at +149 odds. A 43.4% probability produces a 3.3% edge, making this a strong play for today's MLB action.

Yankees vs. Astros over 9 runs (-101)

• Edge: 3.1%
• Probability: 53.4%
• Matchup: Yankees vs. Astros (7:10PM ET, Saturday)

A 3.1% edge on a 53.4% probability makes over 9 runs at -101 odds a solid value play in today's Yankees vs. Astros matchup.

Royals ML (-136)

• Edge: 2.7%
• Probability: 60.4%
• Matchup: Angels vs. Royals (7:10PM ET, Saturday)

Our model projects value on Royals to win at -136 odds. A 60.4% probability produces a 2.7% edge, making Royals the favorable ML play in Saturday’s matchup.

Pirates vs. Brewers over 7.5 runs (-105)

• Edge: 2.5%
• Probability: 53.8%
• Matchup: Pirates vs. Brewers (2:10PM ET, Sunday)

Rounding out our top 10 bets, Pirates vs. Brewers over 7.5 runs at -105 odds shows a 53.8% probability and a 2.5% edge.

MLB best bets summary: Saturday, 4/25/2026

As of 7:02PM ET, here are our top MLB bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Padres vs. Diamondbacks	Under 15.5 Runs	-105 @ FanDuel	8.5%	59.7%
Athletics vs. Rangers	Athletics -1.5	+164 @ DraftKings	7.2%	45.1%
Athletics vs. Rangers	Over 8 Runs	-110 @ BetMGM	6.5%	58.9%
Red Sox vs. Orioles	Over 7.5 Runs	-105 @ DraftKings	4.3%	55.5%
Athletics vs. Rangers	Over 8.5 Runs	-112 @ DraftKings	3.7%	56.5%
Guardians vs. Blue Jays	Over 8 Runs	-105 @ DraftKings	3.6%	54.8%
Angels vs. Royals	Royals -1.5	+149 @ DraftKings	3.3%	43.4%
Yankees vs. Astros	Over 9 Runs	-101 @ DraftKings	3.1%	53.4%
Angels vs. Royals	Royals ML	-136 @ DraftKings	2.7%	60.4%
Pirates vs. Brewers	Over 7.5 Runs	-105 @ DraftKings	2.5%	53.8%

List of upcoming MLB games to bet on [4/25/2026]

• Athletics vs. Rangers (7:05PM ET, Saturday)
• Angels vs. Royals (7:10PM ET, Saturday)
• Yankees vs. Astros (7:10PM ET, Saturday)
• Pirates vs. Brewers (7:10PM ET, Saturday)
• Phillies vs. Braves (7:15PM ET, Saturday)
• Cubs vs. Dodgers (7:15PM ET, Saturday)
• Tigers vs. Reds (7:15PM ET, Saturday)
• Red Sox vs. Orioles (1:35PM ET, Sunday)
• Phillies vs. Braves (1:35PM ET, Sunday)
• Guardians vs. Blue Jays (1:37PM ET, Sunday)
• Tigers vs. Reds (1:40PM ET, Sunday)
• Twins vs. Rays (1:40PM ET, Sunday)
• Pirates vs. Brewers (2:10PM ET, Sunday)
• Nationals vs. White Sox (2:10PM ET, Sunday)
• Yankees vs. Astros (2:10PM ET, Sunday)
• Mariners vs. Cardinals (2:15PM ET, Sunday)
• Athletics vs. Rangers (2:35PM ET, Sunday)
• Padres vs. D-Backs (4:05PM ET, Sunday)
• Marlins vs. Giants (4:05PM ET, Sunday)
• Cubs vs. Dodgers (4:10PM ET, Sunday)

Conclusion

Our MLB best bets are locked and loaded for April 25, 2026, featuring plays such as under 15.5 runs in the Padres vs. Diamondbacks matchup and Athletics -1.5. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.