Free MLB picks today: Saturday's MLB best bets include three over/under plays [9/27/2025]

Today’s free MLB picks for September 27, 2025 are here, with Saturday’s MLB best bets powered by thousands of data simulations analyzing the latest odds and matchups.

These MLB best bets include matchups like Dodgers vs. Mariners and Royals vs. Athletics, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Saturday, September 27, 2025, including our full suite of picks and best bets for today and the week ahead.

List of MLB best bets tonight [9/27, updated 9:32PM ET]

After diving deep into the numbers and running thousands of simulations, our famous predictive analytics model has figured out the best baseball bets for Saturday, September 27, 2025.

Dodgers vs. Mariners over 7 runs (-102)

• Probability: 60%
• Edge: 9.5%
• Matchup: Dodgers vs. Mariners (9:40PM ET, Saturday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Dodgers vs. Mariners game. We recommend an over/under bet on over 7 runs at -102 odds, with our analysis showing a 60% chance of hitting and a compelling edge of 9.5%.

Royals vs. Athletics over 10 runs (-112)

• Probability: 58.9%
• Edge: 6.1%
• Matchup: Royals vs. Athletics (10:05PM ET, Saturday)

Our model has found another strong MLB bet for Saturday's baseball action, this time in the game between the Royals and Athletics. We suggest placing an over/under wager on over 10 runs at -112 odds, with a 58.9% probability delivering a 6.1% edge.

Astros vs. Angels over 9 runs (-105)

• Probability: 58.3%
• Edge: 7.1%
• Matchup: Astros vs. Angels (9:38PM ET, Saturday)

Our model has found another strong MLB bet for Saturday's baseball action, this time in the Astros vs. Angels matchup. We recommend an over/under bet on over 9 runs at -105 odds. Our projections shows a 58.3% probability and 7.1% edge for this wager.

MLB best bets: Saturday, 9/27/2025

As of 9:32PM ET, here are our top three MLB bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Dodgers vs. Mariners	Over 7 Runs	-102 @ DraftKings	60%	9.5%
Royals vs. Athletics	Over 10 Runs	-112 @ DraftKings	58.9%	6.1%
Astros vs. Angels	Over 9 Runs	-105 @ FanDuel	58.3%	7.1%

The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Among today's MLB picks is a -105 over/under bet with a 12.5% edge—the kind of high-upside play that makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 27, 2025.

List of upcoming MLB games to bet on [9/27/2025]

• Astros vs. Angels (9:38PM ET, Saturday)
• Dodgers vs. Mariners (9:40PM ET, Saturday)
• Royals vs. Athletics (10:05PM ET, Saturday)
• Orioles vs. Yankees (3:05PM ET, Sunday)
• Rockies vs. Giants (3:05PM ET, Sunday)
• Twins vs. Phillies (3:05PM ET, Sunday)
• White Sox vs. Nationals (3:05PM ET, Sunday)
• Rays vs. Blue Jays (3:07PM ET, Sunday)
• Dodgers vs. Mariners (3:10PM ET, Sunday)
• Reds vs. Brewers (3:10PM ET, Sunday)
• Pirates vs. Braves (3:15PM ET, Sunday)

More about MLB

The bets on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for September 27, 2025, featuring plays such as over 7 runs in the Dodgers vs. Mariners matchup and over 10 runs in the Royals vs. Athletics matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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