Knicks vs. Spurs prediction: San Antonio to win, Jalen Brunson projected for 30 points in Wednesday's NBA game [12/31/2025]

The San Antonio Spurs and New York Knicks will meet in NBA action at Frost Bank Center on Wednesday, starting at 7:00 PM ET.

Based on updated simulations and today’s injury news, Dimers' proven NBA model predicts the Spurs as the most likely winner of the Knicks vs. Spurs game.

This prediction follows the latest NBA Injury Report, which suggests the Spurs lineup will feature players like Victor Wembanyama, De'Aaron Fox and Stephon Castle, while the Knicks will look to Jalen Brunson, Karl-Anthony Towns and OG Anunoby.

This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Knicks vs. Spurs prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the outcome of Wednesday's NBA matchup between the Knicks and Spurs 10,000 times as part of our NBA predictions coverage.

Our independent predictive model currently gives the Spurs a 64% chance of defeating the Knicks. Our predicted final score has the Spurs winning 118-114.

According to our model, the Spurs (-3.5) have a 52% chance of covering the spread, while the over/under total of 236.5 points has a 54% chance of staying under.

Knicks vs. Spurs odds

We have sourced the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Knicks vs. Spurs picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Wednesday, the top play to make on this game is Spurs to win.

Knicks vs. Spurs player props

Betting on Knicks vs. Spurs NBA player props? We have crunched the numbers to project how each team's leading players will perform at Frost Bank Center.

Jalen Brunson is expected to lead the Knicks with 30 points, 3 rebounds and 7 assists, while Victor Wembanyama is projected to have 24 points, 10 rebounds and 3 assists for the Spurs.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.

Knicks prediction

Our model's projected player stats for the Knicks are:

Spurs prediction

Projected points, rebounds, assists and three-pointers made for the Spurs:

Knicks vs. Spurs game-day updates and essential details

Wednesday's action between the Spurs and Knicks at Frost Bank Center is scheduled to begin at 7:00 PM ET.

• Who: New York Knicks vs. San Antonio Spurs
• Date: Wednesday, December 31, 2025
• Time: 7:00 PM ET/4:00PM PT
• Venue: Frost Bank Center

Conclusion

We predict the Spurs, with a 64% win probability, will likely beat the Knicks on Wednesday, with Victor Wembanyama projected for a game-high 50 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Knicks vs. Spurs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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