Yankees vs. Orioles prediction: Cy Young candidate Max Fried takes on Baltimore tonight [9/18/2025]

The Baltimore Orioles will square off with the New York Yankees in MLB action at Oriole Park at Camden Yards on Thursday, starting at 7:15PM ET.

The Orioles will send Cade Povich (3-7, 5.05 ERA) to the mound, while the Yankees have opted for Cy Young hopeful Max Fried (17-5, 3.03 ERA).

Based on updated simulations, Dimers' advanced MLB model projects the Yankees as the most likely winner of today's game.

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive Yankees vs. Orioles predictions page.

Orioles vs. Yankees prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Thursday's MLB game between the Yankees and Orioles 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Yankees a 62% chance of defeating the Orioles.

According to our model, the bookmakers have got it right, and the Yankees and Orioles each have a 50% chance of covering the run line, while the over/under total of 9 runs has a 51% chance of going over.

Yankees vs. Orioles odds [9/18/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Yankees	Orioles
Run Line	-1.5 (-130)	+1.5 (+110)
Moneyline	-200	+176
Total	o9 (+100)	u9 (-120)

All odds are correct at the time of publication and are subject to change.

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Yankees vs. Orioles picks and best bets

Our model's biggest edge in today's Yankees vs. Orioles matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Yankees vs. Orioles game-day updates and essential details

Thursday's MLB action between the Orioles and Yankees at Oriole Park at Camden Yards is scheduled to start at 7:15PM ET.

• Who: New York Yankees vs. Baltimore Orioles
• Date: Thursday, September 18, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Oriole Park at Camden Yards

Dimers' in-depth preview of Thursday's Yankees vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Yankees vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Yankees, with a 62% win probability, will likely beat the Orioles on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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