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76ers vs. Celtics prediction: Boston favored to win Game 2 [2026 NBA Playoffs]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Philadelphia 76ers vs Boston Celtics predictions for NBA Playoffs Tuesday.
The Boston Celtics will square off with the Philadelphia 76ers in Game 2of their 2026 NBA Playoffs series at TD Garden on Tuesday, starting at 7:00 PM ET.
Based on updated simulation results and today’s injury updates, Dimers' proven NBA model predicts the Celtics as the most likely winner of the 76ers vs. Celtics Game 2 matchup.
This prediction follows the latest NBA Injury Report, which suggests the Celtics lineup will feature players like Jaylen Brown, Jayson Tatum and Payton Pritchard, while the 76ers will be led by Tyrese Maxey, Paul George and VJ Edgecombe.
This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Sixers vs. Sixers prediction: Who will win Game 2?
Using powerful machine learning and data, we have simulated the outcome of Tuesday's NBA Playoffs matchup between the 76ers and Celtics, forming part of our NBA predictions coverage.
Our leading predictive model currently gives the Celtics an 86% chance of defeating the 76ers in Game 2 of the series. Our predicted final score has the Celtics winning 114-101.
According to our model, the 76ers (+14) have a 55% chance of covering the spread, while the 216.5-point over/under has a 51% chance of going over.
76ers vs. Celtics Game 2 odds
We have sourced the best NBA odds in America for this game, which are listed here:
| Bet Type | 76ers | Celtics |
|---|---|---|
| Spread | +14 (-106) | -14 (-114) |
| Moneyline | +730 | -850 |
| Total | o216.5 (-106) | u216.5 (-110) |
All odds are correct at the time of publication and are subject to change.
76ers vs. Celtics picks and best bet for Game 2
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | 76ers +14 | -106 |
| Moneyline | 76ers | +730 |
| Total | Over 216.5 | -106 |
According to our NBA best bets, the top play to make on this game is 76ers +14 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
76ers vs. Celtics Game 2 player props
NBA prop bets are a common way to wager on Tuesday's Philadelphia vs. Boston game without necessarily betting on the outcome. We use the best information available to project how each team's leading players will perform at TD Garden.
Tyrese Maxey is expected to lead the 76ers with 25 points, 4 rebounds and 6 assists, while Jaylen Brown is projected to have 30 points, 8 rebounds and 6 assists for the Celtics.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.
76ers prediction
Our model's projected player stats for the 76ers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Tyrese Maxey | 25 | 4 | 6 | 3 | 46 |
| Paul George | 18 | 6 | 4 | 3 | 35 |
| VJ Edgecombe | 15 | 6 | 4 | 2 | 33 |
| Kelly Oubre | 15 | 6 | 2 | 2 | 29 |
| Quentin Grimes | 9 | 3 | 2 | 1 | 20 |
Celtics prediction
Projected points, rebounds, assists and three-pointers made for the Celtics:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Jaylen Brown | 30 | 8 | 6 | 2 | 54 |
| Jayson Tatum | 26 | 10 | 7 | 3 | 56 |
| P. Pritchard | 16 | 4 | 5 | 2 | 32 |
| Derrick White | 15 | 5 | 6 | 2 | 36 |
| Neemias Queta | 10 | 8 | 2 | 0 | 28 |
Sixers vs. Celtics Game 2 updates and essential details
Tuesday's Game 2 between the Celtics and 76ers in the NBA Playoffs is scheduled to commence at 7:00 PM ET.
- Who: Philadelphia 76ers vs. Boston Celtics
- Date: Tuesday, April 21, 2026
- Time: 7:00 PM ET/4:00PM PT
- Venue: TD Garden
- NBA Playoffs bracket: Updated NBA Playoffs bracket and schedule
The NBA Playoffs is an annual postseason tournament held to decide the league's champion.
A total of 16 teams, including the 76ers and Celtics, made the NBA Playoffs 2026, which consists of four rounds: the First Round, Conference Semifinals, Conference Finals, and NBA Finals.
Each round is played as a best-of-seven series, with the first team to four wins moving on to the next round until a champion is crowned.
Conclusion
We predict the Celtics, with an 86% win probability, will likely beat the 76ers in Tuesday's NBA playoffs matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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