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Read Article 76ers vs. Knicks prediction: New York favored to win Game 2 [2026 NBA Playoffs]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Philadelphia 76ers vs New York Knicks predictions for NBA Playoffs Wednesday.
The New York Knicks and Philadelphia sixers will lock horns in Game 2 of their NBA Playoffs series at Madison Square Garden on Wednesday, with tipoff at 7:00 PM ET.
Based on updated simulations and today’s injury news, Dimers' proven NBA model predicts the Knicks as the most likely winner of the 76ers vs. Knicks Game 2 matchup.
This prediction follows the latest NBA Injury Report, which suggests the Knicks lineup will feature players like Jalen Brunson, Karl-Anthony Towns and OG Anunoby, while the 76ers will look to Tyrese Maxey, Paul George and VJ Edgecombe.
This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Sixers vs. Sixers prediction: Who will win Game 2?
Using innovative machine learning and data, we have simulated the result of Wednesday's NBA Playoffs matchup between the 76ers and Knicks, forming part of our NBA predictions coverage.
Our famous predictive model gives the Knicks a 79% chance of beating the 76ers in Game 2 of the series. Our predicted final score has the Knicks winning 112-102.
According to our model, the 76ers (+10.5) have a 54% chance of covering the spread, while the over/under total of 213.5 points has a 51% chance of going over.
76ers vs. Knicks Game 2 odds
We have sourced the best NBA odds in America for this game, which are listed here:
| Bet Type | 76ers | Knicks |
|---|---|---|
| Spread | +10.5 (-105) | -10.5 (-105) |
| Moneyline | +350 | -450 |
| Total | o213.5 (-106) | u213.5 (-114) |
All odds are correct at the time of publication and are subject to change.
76ers vs. Knicks picks and best bet for Game 2
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | 76ers +10.5 | -105 |
| Moneyline | 76ers | +350 |
| Total | Over 213.5 | -106 |
According to our best NBA bets for Wednesday, the top play to make on this game is 76ers +10.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
76ers vs. Knicks Game 2 player props
Betting on Philadelphia vs. New York NBA prop bets? We use the best information available to project how each team's leading players will perform at Madison Square Garden.
Tyrese Maxey is expected to lead the 76ers with 26 points, 4 rebounds and 6 assists, while Jalen Brunson is projected to have 25 points, 3 rebounds and 7 assists for the Knicks.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.
76ers prediction
Our model's projected player stats for the 76ers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Tyrese Maxey | 26 | 4 | 6 | 3 | 47 |
| Paul George | 19 | 6 | 4 | 3 | 39 |
| VJ Edgecombe | 16 | 6 | 4 | 2 | 36 |
| Kelly Oubre | 14 | 6 | 2 | 2 | 28 |
| Quentin Grimes | 9 | 3 | 2 | 1 | 19 |
Knicks prediction
Projected points, rebounds, assists and three-pointers made for the Knicks:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Jalen Brunson | 25 | 3 | 7 | 3 | 44 |
| K. Towns | 20 | 13 | 4 | 2 | 49 |
| OG Anunoby | 20 | 6 | 2 | 3 | 39 |
| Mikal Bridges | 13 | 3 | 3 | 2 | 26 |
| Josh Hart | 13 | 9 | 6 | 1 | 37 |
Sixers vs. Knicks Game 2 updates and essential details
Wednesday's Game 2 between the Knicks and 76ers in the NBA Playoffs is scheduled to start at 7:00 PM ET.
- Who: Philadelphia 76ers vs. New York Knicks
- Date: Wednesday, May 6, 2026
- Time: 7:00 PM ET/4:00PM PT
- Venue: Madison Square Garden
- NBA Playoffs bracket: Updated NBA Playoffs bracket and schedule
The NBA Playoffs is an annual elimination tournament held to determine the league's champion.
A total of 16 teams, including the 76ers and Knicks, made the 2026 NBA Playoffs, which spans four rounds: the First Round, Conference Semifinals, Conference Finals, and NBA Finals.
Each round of the NBA Playoffs is played as a best-of-seven series, with the first team to four wins advancing to the next round until a champion is crowned.
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Conclusion
We predict the Knicks, with a 79% win probability, will likely beat the 76ers in Wednesday's NBA playoffs matchup.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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