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Pirates vs. Brewers prediction: Why Milwaukee is favored to win Saturday's MLB matchup [4/25/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Pittsburgh Pirates vs Milwaukee Brewers predictions for MLB Saturday.
MLB action continues on Saturday at 7:10 PM ET as the Pittsburgh Pirates take on the Milwaukee Brewers at American Family Field.
Jacob Misiorowski (1-2, 3.04 ERA) will start on the mound for the Brewers, while the Pirates have opted for Mitch Keller (2-1, 2.79 ERA).
Based on the latest simulations, Dimers' proven MLB model predicts the Brewers as the most likely winner of the Pirates vs. Brewers game.
This article offers an expanded analysis of Saturday's matchup, including best bets and picks.
Pirates vs. Brewers prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the outcome of Saturday's MLB matchup between the Pirates and Brewers, forming part of our MLB predictions coverage.
Our famous predictive model gives the Brewers a 57% chance of defeating the Pirates.
According to our model, the Pirates (+1.5) have a 61% chance of covering the run line, while the 7.5-run over/under has a 55% chance of going over.
Pirates vs. Brewers odds [4/25/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Pirates | Brewers |
|---|---|---|
| Run Line | +1.5 (-178) | -1.5 (+157) |
| Moneyline | +120 | -138 |
| Total | o7.5 (-118) | u7.5 (-104) |
All odds are correct at the time of publication and are subject to change.
Pirates vs. Brewers picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Brewers -1.5 | +157 |
| Moneyline | Brewers | -138 |
| Total | Over 7.5 | -118 |
According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Pirates vs. Brewers game-day updates and essential details
Saturday's MLB game between the Brewers and Pirates at American Family Field is scheduled to begin at 7:10 PM ET.
- Who: Pittsburgh Pirates vs. Milwaukee Brewers
- Date: Saturday, April 25, 2026
- Time: 7:10 PM ET/4:10PM PT
- Venue: American Family Field
Conclusion
We predict the Brewers, with a 57% win probability, will likely beat the Pirates in Saturday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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