May 20, 2026
Athletics vs. Angels prediction: Athletics favored to win Wednesday's MLB matchup [5/20/2026]
Read Article Pirates vs. Cardinals prediction: St. Louis favored to win Tuesday's MLB matchup [5/19/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Pittsburgh Pirates vs St. Louis Cardinals predictions for MLB Tuesday.
The St. Louis Cardinals and Pittsburgh Pirates are scheduled to meet in MLB action at Busch Stadium on Tuesday, starting at 7:45 PM ET.
Matthew Liberatore (2-2, 4.40 ERA) will get the ball for the Cardinals, while the Pirates are going with Mitch Keller (4-2, 3.59 ERA).
Based on the latest simulation results, Dimers' proven MLB model gives the Cardinals a slight edge with a 52% win probability over the Pirates.
This article offers further insights into Tuesday's Pirates vs. Cardinals matchup, including best bets and picks.
Pirates vs. Cardinals prediction: Who will win?
Using powerful machine learning and data, we have simulated the result of Tuesday's MLB game between the Pirates and Cardinals, forming part of our MLB predictions coverage.
Our leading predictive model gives the Cardinals a 52% chance of defeating the Pirates.
According to our model, the 8-run over/under has a 53% chance of going over.
Pirates vs. Cardinals odds [5/19/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Pirates | Cardinals |
|---|---|---|
| Moneyline | -104 | -110 |
| Total | o8 (-105) | u8 (-109) |
All odds are correct at the time of publication and are subject to change.
Pirates vs. Cardinals picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Moneyline | Cardinals | -110 |
| Total | Over 8 | -105 |
According to our MLB best bets, the top play to make on this game is Over 8 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Pirates vs. Cardinals game-day updates and essential details
Tuesday's MLB matchup between the Cardinals and Pirates at Busch Stadium is scheduled to begin at 7:45 PM ET.
- Who: Pittsburgh Pirates vs. St. Louis Cardinals
- Date: Tuesday, May 19, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict the Cardinals, with a 52% win probability, will likely beat the Pirates in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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