Blue Jays vs. Yankees prediction: Yankees favored to win Wednesday's MLB matchup [5/20/2026]

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Written by Jason Bevilacqua

Get Toronto Blue Jays vs New York Yankees predictions for MLB Wednesday.

Toronto Blue Jays-New York Yankees Predictions and Game Preview.
Toronto Blue Jays vs. New York Yankees MLB prediction for Wednesday, May 20, 2026.

The New York Yankees will take on the Toronto Blue Jays in MLB action at Yankee Stadium on Wednesday, beginning at 7:05 PM ET.

Cam Schlittler (6-1, 1.35 ERA) will be on the bump for the Yankees, while the Blue Jays have opted for Trey Yesavage (1-1, 1.40 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Yankees as the most likely winner of the Blue Jays vs. Yankees game.

This article offers a closer look at Wednesday's matchup, including best bets and picks.

Blue Jays vs. Yankees prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB game between the Blue Jays and Yankees, forming part of our MLB predictions coverage.

Our independent predictive model gives the Yankees a 60% chance of beating the Blue Jays.

According to our model, the Blue Jays (+1.5) have a 57% chance of covering the run line, while the 7.5-run over/under has a 56% chance of going over.

 

Blue Jays vs. Yankees odds [5/20/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type Blue Jays Yankees
Run Line +1.5 (-140) -1.5 (+125)
Moneyline +146 -168
Total o7.5 (-104) u7.5 (-102)

All odds are correct at the time of publication and are subject to change.

Blue Jays vs. Yankees picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Run Line Blue Jays +1.5 -140
Moneyline Blue Jays +146
Total Over 7.5 -104

According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

 

Blue Jays vs. Yankees game-day updates and essential details

Wednesday's MLB action between the Yankees and Blue Jays at Yankee Stadium is scheduled to start at 7:05 PM ET.

Conclusion

We predict the Yankees, with a 60% win probability, will likely beat the Blue Jays in Wednesday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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