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Portland Timbers vs. San Diego FC prediction, odds, MLS Cup first round picks [11/1/2025]

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Written by Jason Bevilacqua

Get Portland Timbers vs San Diego FC predictions for MLS Cup Saturday.

Portland Timbers-San Diego FC Predictions and Game Preview.
Portland Timbers vs. San Diego FC MLS prediction for Saturday, November 1, 2025.

Portland will square off with San Diego FC in the MLS Cup first round at Providence Park on Saturday, commencing at 9:30PM ET.

Based on the latest simulations, Dimers' proven MLS model projects Portland as the most likely winner of the Portland vs. San Diego FC game.

This article offers further insights into Saturday's matchup, including best bets and picks.

Portland Timbers vs. San Diego FC prediction: Who will win MLS Cup first round matchup?

Using innovative machine learning and data, we have simulated the result of Saturday's MLS matchup between Portland and San Diego FC 10,000 times as part of our MLS predictions coverage.

Our independent predictive model suggests a 39.0% chance of Portland winning, a 36.8% chance for San Diego FC, and a 24.2% chance of a draw.

 

Portland Timbers vs. San Diego FC - MLS Cup first round odds

We have sourced the best MLS odds in America for this game, which are listed here:

Market Portland San Diego FC Draw
Moneyline +200 +115 +275

All odds are correct at the time of publication and are subject to change.

Portland Timbers vs. San Diego FC picks and best bet for MLS Cup first round

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Moneyline Portland +200
According to our MLS best bets, the top play to make on this game is Portland to win.

 

Portland Timbers vs. San Diego FC: Correct score predictions

Here are the top three most likely final scoresaccording to our model, with a 1-1 draw being the most probable:

Final Score Probability
POT 1-1 San Diego FC 11.1%
POT 2-1 San Diego FC 8.5%
POT 1-2 San Diego FC 8.3%

These predictions are based on each team's average score after 10,000 simulations, which means the most likely correct score may differ from our predicted winner.

Portland Timbers vs. San Diego FC MLS Cup first round updates and essential details

Saturday's matchup between Portland and San Diego FC in MLS at Providence Park is scheduled to begin at 9:30PM ET.

Sports betting deal available for Saturday

To make the most of Saturday's exciting day of sports, headlined by college football Saturday games, check out details on the latest Bet365 bonus code "DIMERS" that scores you $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

According to our computer model, Portland has a 39.0% win probability on Saturday, San Diego FC has a 36.8% win probability, and there is a 24.2% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Portland vs. San Diego FC insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLS

Stay informed with the latest MLS betting news and parlay picks throughout the season.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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