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Spurs vs. Grizzlies prediction: San Antonio to win, Victor Wembanyama projected for big game in Wednesday's NBA matchup [3/25/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get San Antonio Spurs vs Memphis Grizzlies predictions for NBA Wednesday.
NBA action continues on Wednesday at 8:00 PM ET as the favored San Antonio Spurs lock horns with the Memphis Grizzlies at FedExForum.
Based on updated simulation results and today’s injury updates, Dimers' advanced NBA model predicts the Spurs as the most likely winner of the Spurs vs. Grizzlies game.
This prediction follows the latest NBA Injury Report, which suggests the Grizzlies lineup will feature players like GG Jackson, Olivier-Maxence Prosper and Cedric Coward, while the Spurs will rely on Victor Wembanyama, Stephon Castle and Keldon Johnson.
This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Spurs vs. Grizzlies prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the outcome of Wednesday's NBA game between the Spurs and Grizzlies, forming part of our NBA predictions coverage.
Our independent predictive model gives the Spurs an 88% chance of beating the Grizzlies. Our predicted final score has the Spurs winning 122-108.
According to our model, the Grizzlies (+16.5) have a 58% chance of covering the spread, while the over/under total of 232.5 points has a 53% chance of staying under.
Spurs vs. Grizzlies odds
We have researched the best NBA odds in America for this game, which are listed here:
| Bet Type | Spurs | Grizzlies |
|---|---|---|
| Spread | -16.5 (-112) | +16.5 (-105) |
| Moneyline | -1600 | +950 |
| Total | o232.5 (-115) | u232.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Spurs vs. Grizzlies picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Grizzlies +16.5 | -105 |
| Moneyline | Grizzlies | +950 |
| Total | Under 232.5 | -105 |
According to our best NBA bets for Wednesday, the top play to make on this game is Grizzlies +16.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Spurs vs. Grizzlies player props
Looking for San Antonio vs. Memphis NBA player props? We have crunched the numbers to project how each team's leading players will perform at FedExForum.
Victor Wembanyama is expected to lead the Spurs with 29 points, 12 rebounds and 4 assists, while GG Jackson is projected to have 14 points, 5 rebounds and 2 assists for the Grizzlies.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.
Spurs prediction
Our model's projected player stats for the Spurs are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| V. Wembanyama | 29 | 12 | 4 | 3 | 60 |
| Stephon Castle | 17 | 5 | 8 | 1 | 41 |
| Keldon Johnson | 15 | 6 | 1 | 1 | 27 |
| Dylan Harper | 15 | 4 | 5 | 1 | 33 |
| Devin Vassell | 14 | 4 | 3 | 2 | 27 |
Grizzlies prediction
Projected points, rebounds, assists and three-pointers made for the Grizzlies:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| GG Jackson | 14 | 5 | 2 | 1 | 28 |
| O. Prosper | 12 | 4 | 1 | 1 | 23 |
| Cedric Coward | 11 | 5 | 3 | 1 | 25 |
| Javon Small | 11 | 4 | 4 | 2 | 24 |
| T. Hendricks | 10 | 4 | 1 | 1 | 23 |
Spurs vs. Grizzlies game-day updates and essential details
Wednesday's matchup between the Grizzlies and Spurs at FedExForum is scheduled to begin at 8:00 PM ET.
- Who: San Antonio Spurs vs. Memphis Grizzlies
- Date: Wednesday, March 25, 2026
- Time: 8:00 PM ET/5:00PM PT
- Venue: FedExForum
Conclusion
We predict the Spurs, with an 88% win probability, will likely beat the Grizzlies on Wednesday, with Victor Wembanyama projected for a game-high 60 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Spurs vs. Grizzlies insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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