San Diego FC vs. Portland Timbers prediction, odds, MLS Cup first round picks [11/9/2025]

San Diego FC will take on Portland in the MLS Cup first round on Sunday, starting at 9:00PM ET.

Based on updated simulation results, Dimers' advanced MLS model predicts San Diego FC as the most likely winner of the San Diego FC vs. Portland game.

This article offers further insights into Sunday's matchup, including best bets and picks.

San Diego FC vs. Portland Timbers prediction: Who will win MLS Cup first round matchup?

Using innovative machine learning and statistical analysis, we have simulated the result of Sunday's MLS matchup between San Diego FC and Portland 10,000 times as part of our MLS predictions coverage.

Our independent predictive model suggests a 62.1% chance of San Diego FC winning, a 17.4% chance for Portland, and a 20.5% chance of a draw.

Additionally, the over/under total of 2.5 goals has a 59% chance of going over, according to our model.

San Diego FC vs. Portland Timbers - MLS Cup first round odds

We have sourced the best MLS odds in America for this game, which are listed here:

Moneyline

Total Goals

All odds are correct at the time of publication and are subject to change.

San Diego FC vs. Portland Timbers picks and best bet for MLS Cup first round

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our MLS best bets, the top play to make on this game is Portland to win.

San Diego FC vs. Portland Timbers: Correct score predictions

The top three most likely final scores, according to our model, are listed below, with a 2-0 San Diego FC win being the most probable:

These predictions are based on each team's average score after 10,000 simulations.

San Diego FC vs. Portland Timbers MLS Cup first round updates and essential details

Sunday's action between San Diego FC and Portland is scheduled to begin at 9:00PM ET.

• Who: San Diego FC vs. Portland Timbers
• Date: Sunday, November 9, 2025
• Time: 9:00PM ET/6:00PM PT

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Conclusion

According to our computer model, San Diego FC has a 62.1% win probability on Sunday, Portland has a 17.4% win probability, and there is a 20.5% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate San Diego FC vs. Portland insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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