Padres vs. Cubs prediction: Tight battle projected in updated analysis for Game 2 of 2025 Wild Card Series

The Chicago Cubs will face the San Diego Padres in Game 2 of their Wild Card Series at Wrigley Field on Wednesday, beginning at 3:08PM ET.

Andrew Kittredge (0-0, 0.00 ERA) will be the starting pitcher for the Cubs, pitting him against Dylan Cease (0-0, 0.00 ERA) for the Padres.

Based on the latest simulation results, Dimers' advanced MLB model predicts an equal chance for both the Cubs and Padres to win today's game.

"Our team has simulated the outcome of Wednesday's Padres-Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Cubs and Padres, making it a highly competitive matchup."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Padres vs. Cubs predictions page.

Padres vs. Cubs prediction: Who will win?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's MLB game between the Padres and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model can't split the two teams, giving both the Padres and Cubs a 50% chance of winning the game.

According to our model, the over/under total of 6.5 runs has a 65% chance of going over.

Padres vs. Cubs odds [Wild Card Series Game 2]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Cubs
Moneyline	-105	-110
Total	o6.5 (-110)	u6.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Cubs picks and best bets

Our model's biggest edge in today's Padres vs. Cubs matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Padres vs. Cubs game-day updates and essential details

Wednesday's MLB matchup between the Cubs and Padres at Wrigley Field is scheduled to start at 3:08PM ET.

• Who: San Diego Padres vs. Chicago Cubs
• Date: Wednesday, October 1, 2025
• Time: 3:08PM ET/12:08PM PT
• Venue: Wrigley Field

Dimers' comprehensive preview of Wednesday's Padres vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict a close game between the Padres and Cubs on Wednesday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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