May 20, 2026
Blue Jays vs. Yankees prediction: Yankees favored to win Wednesday's MLB matchup [5/20/2026]
Read Article Giants vs. Diamondbacks prediction: Why Arizona is favored to win Wednesday's MLB matchup [5/20/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get San Francisco Giants vs Arizona Diamondbacks predictions for MLB Wednesday.
The Arizona Diamondbacks and San Francisco Giants will meet in MLB action at Chase Field on Wednesday, starting at 3:40 PM ET.
Merrill Kelly (3-3, 5.91 ERA) will start for the Diamondbacks, up against Tyler Mahle (1-5, 5.59 ERA) for the Giants.
Based on the latest simulation results, Dimers' proven MLB model gives the Diamondbacks a slight edge with a 52% win probability over the Giants.
This article offers a closer look at Wednesday's Giants vs. Diamondbacks matchup, including best bets and picks.
Giants vs. Diamondbacks prediction: Who will win?
Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Giants and Diamondbacks, forming part of our MLB predictions coverage.
Our leading predictive model gives the Diamondbacks a 52% chance of beating the Giants.
According to our model, the 8.5-run over/under has a 58% chance of going over.
Giants vs. Diamondbacks odds [5/20/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Giants | Diamondbacks |
|---|---|---|
| Moneyline | -106 | -110 |
| Total | o8.5 (-110) | u8.5 (-107) |
All odds are correct at the time of publication and are subject to change.
Giants vs. Diamondbacks picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Moneyline | Diamondbacks | -110 |
| Total | Over 8.5 | -110 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Giants vs. Diamondbacks game-day updates and essential details
Wednesday's MLB matchup between the Diamondbacks and Giants at Chase Field is scheduled to start at 3:40 PM ET.
- Who: San Francisco Giants vs. Arizona Diamondbacks
- Date: Wednesday, May 20, 2026
- Time: 3:40 PM ET/12:40PM PT
- Venue: Chase Field
Conclusion
We predict the Diamondbacks, with a 52% win probability, will likely beat the Giants in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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