Cardinals vs. Diamondbacks prediction: Why Arizona is favored to win Saturday's MLB matchup [7/18/2026]
Get St. Louis Cardinals vs Arizona Diamondbacks predictions for MLB Saturday.
The Arizona Diamondbacks will face the St. Louis Cardinals, in what is expected to be a close MLB game, at Chase Field on Saturday, beginning at 4:10 PM ET.
The Diamondbacks will have Brandon Pfaadt (3-1, 4.70 ERA) as their starting pitcher, pitting him against Dustin May (5-6, 4.55 ERA) for the Cardinals.
Based on the latest simulation results, Dimers' advanced MLB model gives the Diamondbacks a slight edge with a 53.6% win probability over the Cardinals.
This article offers an expanded analysis of Saturday's Cardinals vs. Diamondbacks matchup, including best bets and picks.
Cardinals vs. Diamondbacks prediction: Who will win and cover?
Our independent predictive model currently gives the Diamondbacks a 53.6% chance of defeating the Cardinals.
According to our model, the Cardinals (+1.5) have a 62.9% chance of covering the run line, while the over/under total of 9.5 runs has a 52.4% chance of staying under,.
Cardinals vs. Diamondbacks odds [7/18/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Diamondbacks |
|---|---|---|
| Run Line | +1.5 (-205) | -1.5 (+170) |
| Moneyline | +108 | -111 |
| Total | o9.5 (+122) | u9.5 (-127) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Diamondbacks picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Diamondbacks -1.5 | +170 |
| Moneyline | Diamondbacks | -111 |
| Total | Over 9.5 | +122 |
According to our MLB best bets, the top play to make on this game is Over 9.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Diamondbacks game-day updates and essential details
Saturday's MLB game between the Diamondbacks and Cardinals at Chase Field is scheduled to begin at 4:10 PM ET.
- Who: St. Louis Cardinals vs. Arizona Diamondbacks
- Date: Saturday, July 18, 2026
- Time: 4:10 PM ET/1:10PM PT
- Venue: Chase Field
Conclusion
We predict the Diamondbacks, with a 53.6% win probability, will likely beat the Cardinals in Saturday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
