May 25, 2026
Nationals vs. Guardians prediction: Why Cleveland is favored to win Monday's MLB matchup [5/25/2026]
Read Article Cardinals vs. Brewers prediction: Why Milwaukee is favored to win Monday's MLB matchup [5/25/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Milwaukee Brewers predictions for MLB Monday.
The Milwaukee Brewers will square off with the St. Louis Cardinals in MLB action at American Family Field on Monday, commencing at 2:10 PM ET.
The Brewers will send Jacob Misiorowski (4-2, 1.90 ERA) to the mound, up against Matthew Liberatore (2-2, 4.70 ERA) for the Cardinals.
Based on the latest simulation results, Dimers' proven MLB model predicts the Brewers as the most likely winner of the Cardinals vs. Brewers game.
This article offers an expanded analysis of Monday's matchup, including best bets and picks.
Cardinals vs. Brewers prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the result of Monday's MLB game between the Cardinals and Brewers, forming part of our MLB predictions coverage.
Our independent predictive model currently gives the Brewers a 65% chance of defeating the Cardinals.
According to our model, the Cardinals (+1.5) have a 52% chance of covering the run line, while the 7.5-run over/under has a 55% chance of going over.
Cardinals vs. Brewers odds [5/25/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Brewers |
|---|---|---|
| Run Line | +1.5 (-102) | -1.5 (+100) |
| Moneyline | +190 | -220 |
| Total | o7.5 (-102) | u7.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Brewers picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cardinals +1.5 | -102 |
| Moneyline | Cardinals | +190 |
| Total | Over 7.5 | -102 |
According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Brewers game-day updates and essential details
Monday's MLB game between the Brewers and Cardinals at American Family Field is scheduled to begin at 2:10 PM ET.
- Who: St. Louis Cardinals vs. Milwaukee Brewers
- Date: Monday, May 25, 2026
- Time: 2:10 PM ET/11:10AM PT
- Venue: American Family Field
Conclusion
We predict the Brewers, with a 65% win probability, will likely beat the Cardinals in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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