...
...
Read Article
Cardinals vs. Pirates prediction: Why Pittsburgh is favored to win Tuesday's MLB matchup [4/28/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Pittsburgh Pirates predictions for MLB Tuesday.
The Pittsburgh Pirates will face the St. Louis Cardinals in MLB action at PNC Park on Tuesday, beginning at 6:40 PM ET.
Braxton Ashcraft (1-1, 2.43 ERA) will start for the Pirates, up against Kyle Leahy (2-3, 5.62 ERA) for the Cardinals.
Based on the latest simulations, Dimers' proven MLB model predicts the Pirates as the most likely winner of the Cardinals vs. Pirates game.
This article offers further insights into Tuesday's matchup, including best bets and picks.
Cardinals vs. Pirates prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the outcome of Tuesday's MLB game between the Cardinals and Pirates, forming part of our MLB predictions coverage.
Our famous predictive model gives the Pirates a 58% chance of defeating the Cardinals.
According to our model, the Cardinals (+1.5) have a 60% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.
Cardinals vs. Pirates odds [4/28/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Pirates |
|---|---|---|
| Run Line | +1.5 (-152) | -1.5 (+135) |
| Moneyline | +136 | -155 |
| Total | o8.5 (-102) | u8.5 (-115) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Pirates picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cardinals +1.5 | -152 |
| Moneyline | Cardinals | +136 |
| Total | Over 8.5 | -102 |
According to our best MLB bets, the top play to make on this game is Cardinals +1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Pirates game-day updates and essential details
Tuesday's MLB game between the Pirates and Cardinals at PNC Park is scheduled to commence at 6:40 PM ET.
- Who: St. Louis Cardinals vs. Pittsburgh Pirates
- Date: Tuesday, April 28, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: PNC Park
Conclusion
We predict the Pirates, with a 58% win probability, will likely beat the Cardinals in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
Advertiser disclosure