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Cardinals vs. Pirates prediction: Why Pittsburgh is favored to win Wednesday's MLB matchup [4/29/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Pittsburgh Pirates predictions for MLB Wednesday.
MLB action continues on Wednesday at 6:40 PM ET as the St. Louis Cardinals take on the Pittsburgh Pirates at PNC Park.
The Pirates will send Bubba Chandler (1-2, 4.88 ERA) to the mound, while the Cardinals have opted for Andre Pallante (2-2, 4.26 ERA).
Based on the latest simulations, Dimers' proven MLB model predicts the Pirates as the most likely winner of the Cardinals vs. Pirates game.
This article offers further insights into Wednesday's matchup, including best bets and picks.
Cardinals vs. Pirates prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Cardinals and Pirates, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Pirates a 55% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 63% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of going over.
Cardinals vs. Pirates odds [4/29/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Pirates |
|---|---|---|
| Run Line | +1.5 (-188) | -1.5 (+165) |
| Moneyline | +114 | -130 |
| Total | o8.5 (-110) | u8.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Pirates picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Pirates -1.5 | +165 |
| Moneyline | Cardinals | +114 |
| Total | Over 8.5 | -110 |
According to our best MLB bets, the top play to make on this game is Pirates -1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Pirates game-day updates and essential details
Wednesday's MLB matchup between the Pirates and Cardinals at PNC Park is scheduled to start at 6:40 PM ET.
- Who: St. Louis Cardinals vs. Pittsburgh Pirates
- Date: Wednesday, April 29, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: PNC Park
Conclusion
We predict the Pirates, with a 55% win probability, will likely beat the Cardinals in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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