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Read Article Blue Jays vs. Yankees prediction: Yankees favored to win Thursday's MLB matchup [5/21/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Toronto Blue Jays vs New York Yankees predictions for MLB Thursday.
The New York Yankees will face the Toronto Blue Jays in MLB action at Yankee Stadium on Thursday, starting at 7:05 PM ET.
Carlos Rodón (0-1, 5.62 ERA) will start for the Yankees, pitting him against Braydon Fisher (2-1, 3.08 ERA) for the Blue Jays.
Based on updated simulations, Dimers' advanced MLB model predicts the Yankees as the most likely winner of the Blue Jays vs. Yankees game.
This article offers a closer look at Thursday's matchup, including best bets and picks.
Blue Jays vs. Yankees prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the outcome of Thursday's MLB game between the Blue Jays and Yankees, forming part of our MLB predictions coverage.
Our famous predictive model gives the Yankees a 58% chance of beating the Blue Jays.
According to our model, the Blue Jays (+1.5) have a 59% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of going over.
Blue Jays vs. Yankees odds [5/21/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Blue Jays | Yankees |
|---|---|---|
| Run Line | +1.5 (-169) | -1.5 (+146) |
| Moneyline | +124 | -144 |
| Total | o8.5 (+100) | u8.5 (-122) |
All odds are correct at the time of publication and are subject to change.
Blue Jays vs. Yankees picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Yankees -1.5 | +146 |
| Moneyline | Yankees | -144 |
| Total | Over 8.5 | +100 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Blue Jays vs. Yankees game-day updates and essential details
Thursday's MLB action between the Yankees and Blue Jays at Yankee Stadium is scheduled to commence at 7:05 PM ET.
- Who: Toronto Blue Jays vs. New York Yankees
- Date: Thursday, May 21, 2026
- Time: 7:05 PM ET/4:05PM PT
- Venue: Yankee Stadium
Conclusion
We predict the Yankees, with a 58% win probability, will likely beat the Blue Jays in Thursday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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