Cubs vs. Brewers prediction: Why Milwaukee is favored to win Game 1 of NLDS [10/4/2025]

The Milwaukee Brewers will take on the Chicago Cubs in Game 1 of the National League Division Series at American Family Field on Saturday, commencing at 2:08PM ET.

Cy Young hopeful Freddy Peralta (0-0, 0.00 ERA in 2025 postseason) will be on the bump for the Brewers, pitting him against Matthew Boyd (0-0, 2.08 ERA) for the Cubs.

Based on updated simulation results, Dimers' advanced MLB model projects the Brewers as the most likely winner of today's game.

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Cubs vs. Brewers predictions page.

Cubs vs. Brewers prediction: Who will win Game 1?

Using trusted machine learning and data, we have simulated the outcome of Saturday's MLB game between the Cubs and Brewers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Brewers a 54% chance of defeating the Cubs.

According to our model, the Cubs (+1.5) have a 64% chance of covering the run line, while the 7.5-run over/under has a 62% chance of going over.

Cubs vs. Brewers Game 1 odds [10/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Brewers
Run Line	+1.5 (-180)	-1.5 (+160)
Moneyline	+120	-138
Total	o7.5 (-114)	u7.5 (-103)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Brewers picks and best bets for Game 1

Our model's strongest edge in today's Cubs vs. Brewers matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Cubs vs. Brewers game-day updates and essential details

Saturday's MLB action between the Brewers and Cubs at American Family Field is scheduled to start at 2:08PM ET.

• Who: Chicago Cubs vs. Milwaukee Brewers
• Date: Saturday, October 4, 2025
• Time: 2:08PM ET/11:08AM PT
• Venue: American Family Field

Dimers' in-depth preview of Saturday's Cubs vs. Brewers matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Brewers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Brewers, with a 54% win probability, will likely beat the Cubs on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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