Reds vs. Mariners prediction: Seattle favored to win Wednesday's MLB matchup [7/22/2026]
Get Cincinnati Reds vs Seattle Mariners predictions for MLB Wednesday.
MLB action continues on Wednesday at 3:40 PM ET as the Cincinnati Reds take on the Seattle Mariners at T-Mobile Park.
Emerson Hancock (6-4, 3.17 ERA) will start on the mound for the Mariners, while the Reds have opted for Brady Singer (4-9, 4.56 ERA).
Based on the latest simulation results, Dimers' advanced MLB model predicts the Mariners as the most likely winner of the Reds vs. Mariners game.
This article offers further insights into Wednesday's matchup, including best bets and picks.
Reds vs. Mariners prediction: Who will win and cover?
Our leading predictive model currently gives the Mariners a 58.5% chance of beating the Reds.
According to our model, the Reds (+1.5) have a 58.5% chance of covering the run line, while the 8.5-run over/under has a 50.9% chance of staying under,.
Reds vs. Mariners odds [7/22/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Reds | Mariners |
|---|---|---|
| Run Line | +1.5 (-150) | -1.5 (+145) |
| Moneyline | +138 | -138 |
| Total | o8.5 (+113) | u8.5 (-117) |
All odds are correct at the time of publication and are subject to change.
Reds vs. Mariners picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Mariners -1.5 | +145 |
| Moneyline | Mariners | -138 |
| Total | Over 8.5 | +113 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Reds vs. Mariners game-day updates and essential details
Wednesday's MLB matchup between the Mariners and Reds at T-Mobile Park is scheduled to begin at 3:40 PM ET.
- Who: Cincinnati Reds vs. Seattle Mariners
- Date: Wednesday, July 22, 2026
- Time: 3:40 PM ET/12:40PM PT
- Venue: T-Mobile Park
Conclusion
We predict the Mariners, with a 58.5% win probability, will likely beat the Reds in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
