Tigers vs. Cubs prediction: Why Cubs are favored to win Wednesday's MLB matchup [7/22/2026]
Get Detroit Tigers vs Chicago Cubs predictions for MLB Wednesday.
The Chicago Cubs and Detroit Tigers will lock horns in MLB action at Wrigley Field on Wednesday, starting at 8:10 PM ET.
The Cubs will have Colin Rea (7-6, 4.74 ERA) as their starting pitcher, while the Tigers have opted for Keider Montero (6-5, 3.22 ERA).
Based on updated simulation results, Dimers' advanced MLB model gives the Cubs a slight edge with a 52.6% win probability over the Tigers.
This article offers a closer look at Wednesday's Tigers vs. Cubs matchup, including best bets and picks.
Tigers vs. Cubs prediction: Who will win and cover?
Our leading predictive model currently gives the Cubs a 52.6% chance of beating the Tigers.
According to our model, the Tigers (+1.5) have a 64.5% chance of covering the run line, while the 7.5-run over/under has a 57.8% chance of going over,.
Tigers vs. Cubs odds [7/22/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Tigers | Cubs |
|---|---|---|
| Run Line | +1.5 (-205) | -1.5 (+170) |
| Moneyline | +108 | -108 |
| Total | o7.5 (-117) | u7.5 (+108) |
All odds are correct at the time of publication and are subject to change.
Tigers vs. Cubs picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cubs -1.5 | +170 |
| Moneyline | Tigers | +108 |
| Total | Over 7.5 | -117 |
According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Tigers vs. Cubs game-day updates and essential details
Wednesday's MLB game between the Cubs and Tigers at Wrigley Field is scheduled to begin at 8:10 PM ET.
- Who: Detroit Tigers vs. Chicago Cubs
- Date: Wednesday, July 22, 2026
- Time: 8:10 PM ET/5:10PM PT
- Venue: Wrigley Field
Conclusion
We predict the Cubs, with a 52.6% win probability, will likely beat the Tigers in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
