The 2026 NFL season opens with one of the widest lines on the Week 1 board: the Arizona Cardinals travel to SoFi Stadium to face the Los Angeles Chargers on Sunday, September 13. Kickoff is still weeks away, but the early markets are already posted, and the
First TD Scorer
market is where the biggest Week 1 payouts live.
Los Angeles is a double-digit favorite in a game the market expects it to control from the front, and the touchdown board reflects that. Omarion Hampton opens as the shortest number on the board to find the end zone first — and
has posted an interesting First TD Scorer price around him.
Featured Prop: Omarion Hampton First TD Scorer (+350)
on Omarion Hampton to score the first touchdown of the game against the Cardinals.
- The board's clear favorite:
Bet365 prices Hampton's Anytime TD at -160, a roughly 61.5% implied chance and comfortably the shortest anytime number in the game. The next name, Jeremiyah Love, is out at +150, which is the gap the book sees between the Chargers' lead back and the rest of the field.
- Predictive Value:
At +350, the First TD market implies roughly a 22.2% chance Hampton opens the scoring. That is short by First TD standards, and it reflects genuine concentration of red-zone work rather than a speculative longshot — Los Angeles' scoring hierarchy runs through him.
- Game script:
A 10.5-point spread and a 47.5-point total point to a game Los Angeles expects to control at home. If the Chargers get out in front early and lean on their backfield, the goal-line volume that makes this prop land arrives naturally.
- The competition:
Love at +950 is the next number on the board, with Ladd McConkey, Keaton Mitchell and Quentin Johnston all at +1100. Trey McBride at +1200 leads the Arizona side of the panel.
Note:
Odds in this article are correct at time of publication and subject to change.
Player Props: Cardinals Vs. Chargers
First & Anytime TD Scorer Odds (Bet365)
| Player |
First TD Odds |
Anytime TD Odds |
| Omarion Hampton |
+350 |
-160 |
| Jeremiyah Love |
+950 |
+150 |
| Ladd McConkey |
+1100 |
+205 |
| Keaton Mitchell |
+1100 |
+220 |
| Quentin Johnston |
+1100 |
+205 |
| Trey McBride |
+1200 |
+185 |
Cardinals Vs. Chargers Betting Preview
Explore the interactive widget below to discover the latest spread, over/under, and moneyline betting odds and probabilities for the Cardinals-Chargers game at SoFi Stadium.
Check out all the important details on the game, as well as the best odds sourced from the top sportsbooks in the country.
Game Details
The key information you need before the Cardinals vs. Chargers NFL game.
- Teams:
vs.
- Date:
Sunday, September 13, 2026
- Kickoff:
4:25 p.m. EDT (1:25 p.m. local PDT)
- Location:
SoFi Stadium, Inglewood, California
- TV:
CBS
- NFL standings:
- NFL injuries:
Odds (Bet365)
Odds for the key markets in the Cardinals-Chargers matchup.
- Spread:
Cardinals +10.5 (-115), Chargers -10.5 (-105)
- Moneyline:
Cardinals +425, Chargers -575
- Total:
Over/Under 47.5 (-110/-110)
The odds and lines presented here are the best available from selected sports betting sites at the time of publication and are subject to change.
| Sportsbook |
New-user offer |
| Bet365 |
(no bonus code required) |
Bet365 Bet Boosts
Bet365 has posted two boosted Same Game Parlays for the opener:
- Justin Time (+450, boosted from +390):
Chargers Moneyline + Justin Herbert 275+ Passing Yards + Justin Herbert 2+ Passing TDs. A $10 stake returns $55.
- Cardinal Rule (+1100, boosted from +925):
Cardinals Moneyline + Jacoby Brissett 225+ Passing Yards + Jacoby Brissett 2+ Passing TDs. A $10 stake returns $120.
Expert Prediction: Cardinals Vs. Chargers
Utilizing state-of-the-art data analysis and advanced algorithms, the experts at
Dimers
have performed 10,000 simulations of the Cardinals vs. Chargers matchup.
According to Dimers' predictive analytics model, the
Chargers are more likely to win
at SoFi Stadium. This prediction is based on the model giving the Chargers an
82% chance
of winning the game, with a projected final score of
Chargers 30, Cardinals 18.
The model also leans to the
Chargers covering the 10.5-point spread, with the projected 12-point margin clearing the number. On the total, the model's projected 48-point combined score sits marginally above Bet365's posted 47.5.
These predictions and probabilities are accurate at the time of publication but are subject to potential changes.
Cardinals Vs. Chargers Best Bet
Our top pick for the Cardinals vs. Chargers game is to bet on the
Chargers -10.5 (-105)
at Bet365.
Dimers' model projects a 12-point Los Angeles win, which clears the number with a point and a half to spare, and laying -105 on the spread is materially cheaper than the -575 the moneyline demands for the same read on the game. This expert betting advice is based on world-class modeling and valuable betting intelligence, designed to help you make more informed decisions.
Final Thoughts: Cardinals Vs. Chargers
Week 1 opens with one of the widest lines on the slate. Los Angeles hosts Arizona as a 10.5-point favorite with the moneyline out to -575, and Bet365's 47.5-point total signals a book expecting the Chargers offense to move the ball freely at SoFi Stadium.
The headline angle is Omarion Hampton in the touchdown market. At +350 to strike first, he is the shortest First TD price on the board — and if you'd rather back him without needing the opening score, Bet365's
-160
anytime price is the more conservative route to the same read on Los Angeles' red-zone hierarchy.
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