Cruz Azul vs. Pumas UNAM prediction, odds, Liga MX picks [5/21/2026]

Using trusted machine learning and data, we have simulated the result of Thursday's Liga MX game between Cruz Azul and Pumas UNAM, forming part of our Liga MX predictions coverage.

Our leading predictive model suggests a 55.0% chance of Cruz Azul winning, a 21.5% chance for Pumas UNAM, and a 23.5% chance of a draw.

Additionally, the over/under total of 2.5 goals has a 52% chance of going over, according to our model.

Cruz Azul vs. Pumas UNAM odds

We have researched the best Liga MX odds in America for this game, which are listed here:

Moneyline

Cruz Azul	Pumas UNAM	Draw
-145	+360	+300

Total Goals

Over 2.5	Under 2.5
-145	+105

All odds are correct at the time of publication and are subject to change.

Cruz Azul vs. Pumas UNAM picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Moneyline	Pumas UNAM	+360
Total Goals	Under 2.5	+105

According to our Liga MX best bets, the top play to make on this game is Pumas UNAM to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Cruz Azul vs. Pumas UNAM: Correct score and BTTS predictions

Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:

Final Score	Probability
CAZ 1-1 PUM	11.2%
CAZ 1-0 PUM	11.1%
CAZ 2-0 PUM	9.8%

When it comes to the both teams to score (BTTS) market, we project a 52.4% chance of both Cruz Azul and Pumas UNAM finding the net and a 47.6% chance that at least one doesn’t.

These predictions are based on each team's average score according to our machine learning model, meaning the most likely correct score may differ from our predicted winner.

Cruz Azul vs. Pumas UNAM game-day updates and essential details

Thursday's action between Cruz Azul and Pumas UNAM is scheduled to commence at 10:00 PM ET.

• Who: Cruz Azul vs. Pumas UNAM
• Date: Thursday, May 21, 2026
• Time: 10:00 PM ET/7:00PM PT

Conclusion

According to our computer model, Cruz Azul has a 55.0% win probability on Thursday, Pumas UNAM has a 21.5% win probability, and there is a 23.5% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.