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Guadalajara vs. Santos Laguna prediction, odds, Liga MX picks [3/14/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Guadalajara vs Santos Laguna predictions for Liga MX Saturday.
Liga MX action continues on Saturday at 7:07 PM ET as Santos Laguna faces off with the favored Guadalajara in the playoffs at Estadio Akron.
Based on updated simulation results, Dimers' proven Liga MX model predicts Guadalajara as the most likely winner of the Guadalajara vs. Santos Laguna game.
This article offers an expanded analysis of Saturday's matchup, including best bets and picks.
Guadalajara vs. Santos Laguna prediction: Who will win?
Using innovative machine learning and data, we have simulated the result of Saturday's Liga MX matchup between Guadalajara and Santos Laguna 10,000 times as part of our Liga MX predictions coverage.
Our independent predictive model currently indicates a 74.6% chance of Guadalajara winning, a 9.4% chance for Santos Laguna, and a 15.9% chance of a draw.
Guadalajara vs. Santos Laguna odds
We have researched the best Liga MX odds in America for this game, which are listed here:
| Market | Guadalajara | Santos Laguna | Draw |
|---|---|---|---|
| Moneyline | -450 | +950 | +550 |
All odds are correct at the time of publication and are subject to change.
Guadalajara vs. Santos Laguna picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Moneyline | Santos Laguna | +950 |
According to our Liga MX best bets, the top play to make on this game is Santos Laguna to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Guadalajara vs. Santos Laguna: Correct score and BTTS predictions
The top three most likely final scores, according to our model, are listed below, with a 2-0 Guadalajara win being the most probable:
| Final Score | Probability |
|---|---|
| GUA 2-0 SLA | 12.4% |
| GUA 1-0 SLA | 10.2% |
| GUA 3-0 SLA | 10% |
When it comes to the both teams to score (BTTS) market, we project a 47.8% chance of both Guadalajara and Santos Laguna finding the net and a 52.2% chance that at least one doesn’t.
Guadalajara vs. Santos Laguna game-day updates and essential details
Saturday's game between Guadalajara and Santos Laguna at Estadio Akron is scheduled to start at 7:07 PM ET.
- Who: Guadalajara vs. Santos Laguna
- Date: Saturday, March 14, 2026
- Time: 7:07 PM ET/4:07PM PT
- Venue: Estadio Akron
Conclusion
According to our computer model, Guadalajara has a 74.6% win probability on Saturday, Santos Laguna has a 9.4% win probability, and there is a 15.9% chance that the game will end in a draw.
AI and automation have enhanced this article to quickly deliver accurate Guadalajara vs. Santos Laguna insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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