NFL best bets today: Week 5 picks include two spread plays [10/5/2025]

Today’s NFL picks for October 5, 2025 are here, with Sunday’s NFL best bets powered by tens of thousands of data simulations analyzing the latest odds and matchups.

These NFL best bets include matchups like Titans vs. Cardinals and Commanders vs. Chargers, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge NFL bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Sunday, October 5, 2025, including our complete suite of picks and best bets for today and the week ahead.

List of NFL best bets today [10/5, updated 4:01PM ET]

After crunching the numbers and conducting thousands of simulations, our leading predictive analytics model has figured out the best football bets for Sunday, October 5, 2025.

Titans +7.5 (-108)

• Probability: 55.8%
• Edge: 3.9%
• Matchup: Titans vs. Cardinals (4:05PM ET, Sunday)

Our model has pinpointed a high-probability NFL betting opportunity today, which comes in the Titans vs. Cardinals matchup. We recommend a spread bet on Titans +7.5 at -108 odds, with our analysis showing a 55.8% chance of hitting and a compelling edge of 3.9%.

Commanders vs. Chargers over 47.5 points (-105)

• Probability: 54.6%
• Edge: 3.4%
• Matchup: Commanders vs. Chargers (4:25PM ET, Sunday)

Our model has found another strong NFL bet for Sunday's sports action, this time in the matchup between the Commanders and Chargers. We suggest placing an over/under wager on over 47.5 points at -105 odds, with a 54.6% probability delivering a 3.4% edge.

Bengals +9.5 (-102)

• Probability: 53.3%
• Edge: 2.8%
• Matchup: Lions vs. Bengals (4:25PM ET, Sunday)

Our model has found another strong NFL bet for Sunday's football action, this time in the Lions vs. Bengals game. We recommend a spread bet on Bengals +9.5 at -102 odds. Our projections shows a 53.3% probability and 2.8% edge for this wager.

NFL best bets: Sunday, 10/5/2025

As of 4:01PM ET, here are our top three NFL bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Titans vs. Cardinals	Titans +7.5	-108 @ DraftKings	55.8%	3.9%
Commanders vs. Chargers	Over 47.5 Points	-105 @ BetMGM	54.6%	3.4%
Lions vs. Bengals	Bengals +9.5	-102 @ FanDuel	53.3%	2.8%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to four NFL picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for October 5, 2025.

List of upcoming NFL games to bet on [10/5/2025]

• Buccaneers vs. Seahawks (4:05PM ET, Sunday)
• Titans vs. Cardinals (4:05PM ET, Sunday)
• Commanders vs. Chargers (4:25PM ET, Sunday)
• Lions vs. Bengals (4:25PM ET, Sunday)
• Patriots vs. Bills (8:20PM ET, Sunday)

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More on NFL

The bets on this page form part of our NFL player props and NFL best bets series.

For more NFL betting content, we have NFL trends for every game, as well as daily NFL betting news and the latest Super Bowl odds and predictions.

Conclusion

Our NFL best bets are locked and loaded for October 5, 2025, featuring plays such as Titans +7.5 and over 47.5 points in the Commanders vs. Chargers matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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