NFL picks straight up: Week 6, 2025

At Dimers.com, we offer NFL picks straight up for Week 6 and beyond, as part of our detailed NFL picks and NFL predictions coverage.

With Week 6 of the NFL season upon us, we've leveraged our cutting-edge predictive analytics model to deliver a list of NFL straight up picks for all 15 games this week.

Gain the edge in your NFL pick 'em contests by following our data-driven NFL Week 6 picks straight up, powered by thousands of game simulations.

Week 6 of the NFL season features 15 games, starting with the Philadelphia Eagles facing the New York Giants on Thursday night and ending with the Chicago Bears taking on the Washington Commanders on Monday.

Before placing any NFL wagers this week, be sure to explore our full list of NFL best bets with Dimers Pro.

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Full list of NFL Week 6 picks straight up

• Eagles (77% win probability)
• Broncos (75%)
• Colts (71%)
• Rams (72%)
• Steelers (72%)
• Jaguars (55%)
• Chargers (65%)
• Cowboys (61%)
• Patriots (62%)
• Raiders (71%)
• Buccaneers (60%)
• Packers (91%)
• Chiefs (59%)
• Bills (61%)
• Commanders (67%)

NFL picks this week straight up: Week 6, 2025

Here are our Week 6 NFL picks, highlighting how likely each team is to win their game this week.

Philadelphia Eagles vs. New York Giants

The Eagles kick off Week 6 against the Giants at MetLife Stadium on Thursday night. According to our model, the Eagles have a 77% chance of winning, while the Giants have a 23% chance.

For Week 6's opening game, our model highlights NFL player props with Saquon Barkley (RB) as the most likely player from the Eagles to score the first TD at 15.6%, while Cam Skattebo (RB) is the top candidate from the Giants at 12.8%.

The Philadelphia Eagles vs. New York Giants game at MetLife Stadium is scheduled for Thursday, October 9 at 8:15pm. All times stated in this article are in Eastern Standard Time (EST).

Denver Broncos vs. New York Jets

For this week's game between the Broncos and the Jets, Denver is more likely to win. Our prediction model gives the Broncos a 75% chance of winning. On the other hand, there is a 25% chance that the Jets will pull off an upset win.

The Denver Broncos vs. New York Jets matchup at Tottenham Hotspur Stadium will take place on Sunday, October 12 at 9:30am.

As the regular season approaches its conclusion, track the top teams with Dimers' updated NFL futures, highlighting top Super Bowl contenders.

Arizona Cardinals vs. Indianapolis Colts

We are picking the Colts to win their game against the Cardinals this week, with our powerful NFL model projecting a 71% win probability for the home team. The Cardinals have a 29% chance of winning.

For betting purposes, the Colts are listed as -6.5 favorites, with the Cardinals' moneyline at +240.

The Arizona Cardinals vs. Indianapolis Colts game at Lucas Oil Stadium is slated for Sunday, October 12 at 1:00pm.

Los Angeles Rams vs. Baltimore Ravens

According to our predictive analytics model, the Rams are the team to beat in this game, with their win probability at 72%. The Ravens, on the other hand, have a 28% chance of winning.

The Los Angeles Rams vs. Baltimore Ravens game at M&T Bank Stadium is set for Sunday, October 12 at 1:00pm.

Cleveland Browns vs. Pittsburgh Steelers

The Steelers have a 72% chance of winning on Sunday afternoon, compared to the Browns' 28% chance of victory. This makes the Pittsburgh Steelers our pick to win at Acrisure Stadium.

The Cleveland Browns vs. Pittsburgh Steelers matchup at Acrisure Stadium is scheduled for Sunday, October 12 at 1:00pm.

Seattle Seahawks vs. Jacksonville Jaguars

The Jaguars are favored to win this game, with our model giving them a 55% chance, while the Seahawks enter the weekend with a 45% chance of securing a win at EverBank Stadium.

When it comes to betting on this game, the Seahawks' moneyline odds are set at -100, with the home team Jaguars listed as +1.5 underdogs.

The Seattle Seahawks vs. Jacksonville Jaguars game at EverBank Stadium will take place on Sunday, October 12 at 1:00pm.

Los Angeles Chargers vs. Miami Dolphins

After 10,000 simulations of Chargers vs. Dolphins this Sunday, our model projects the Chargers as the more likely winners with a probability of 65%. Their opponents, the Dolphins, have a 35% chance of getting the win at home.

The Los Angeles Chargers vs. Miami Dolphins matchup at Hard Rock Stadium is slated for Sunday, October 12 at 1:00pm.

Dallas Cowboys vs. Carolina Panthers

DimersBOT is picking the Cowboys, who have a 61% chance of winning the game, while the Panthers have a 39% chance of an upset win.

The Dallas Cowboys vs. Carolina Panthers game at Bank of America Stadium will take place on Sunday, October 12 at 1:00pm.

New England Patriots vs. New Orleans Saints

The next game of Week 6 sees the Patriots take on the Saints at Caesars Superdome.

We predict the Patriots to win with a probability of 62%, while the Saints are projected to have a win chance of 38%.

As for the Vegas betting odds here, the Saints are listed as +3.5 underdogs, with the Patriots' moneyline odds posted at -185.

The New England Patriots vs. New Orleans Saints game at Caesars Superdome is scheduled for Sunday, October 12 at 1:00pm.

Tennessee Titans vs. Las Vegas Raiders

The likely winner of this matchup is the Raiders, who have a projected win chance of 71%, according to DimersBOT. On the other side of this matchup, the Titans have a projected win probability of 29%.

The Tennessee Titans vs. Las Vegas Raiders matchup at Allegiant Stadium is set for Sunday, October 12 at 4:05pm.

San Francisco 49ers vs. Tampa Bay Buccaneers

We have run our powerful NFL model over this week’s 49ers-Buccaneers clash 10,000 times, with the Buccaneers coming out as the team to pick. Of those 10,000 simulations, the Buccaneers won 5,992 times, with the 49ers winning on 4,008 occasions.

The San Francisco 49ers vs. Tampa Bay Buccaneers game at Raymond James Stadium is scheduled for Sunday, October 12 at 4:25pm.

Cincinnati Bengals vs. Green Bay Packers

Next up is the game between the Bengals and Packers, with our model projecting the home team as the more likely victor, with the Packers rated as having a 91% chance of getting the W. The Bengals, on the other hand, are projected to have a 9% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Bengals' moneyline odds set at +750 for this road game, while the hosting Packers are listed as -14 favorites.

The Cincinnati Bengals vs. Green Bay Packers game at Lambeau Field will take place on Sunday, October 12 at 4:25pm.

Detroit Lions vs. Kansas City Chiefs

Our next straight up pick this week is for the Chiefs to get the win against the Lions. After running 10,000 simulations of this matchup, the Kansas City have a win probability of 59%, with the Lions at 41%.

The Detroit Lions vs. Kansas City Chiefs game at GEHA Field at Arrowhead Stadium is slated for Sunday, October 12 at 8:20pm.

Buffalo Bills vs. Atlanta Falcons

With a win probability of 61% on Monday night, our straight up pick for this game is the Bills, while their opponent, the Falcons, have a projected win chance of 39%.

The Buffalo Bills vs. Atlanta Falcons game at Mercedes-Benz Stadium will take place on Monday, October 13 at 7:15pm.

For a different angle on this week's NFL action, explore our NFL trends to find the latest player prop trends.

Chicago Bears vs. Washington Commanders

The team to pick here is the Commanders, who have a 67% chance of winning their matchup against the Bears this Sunday night.

Looking at the betting odds for this Monday Night Football clash, the Commanders are listed as -4.5 favorites at home, with the Bears' moneyline odds available at +190.

The Chicago Bears vs. Washington Commanders game at Northwest Stadium is scheduled for Monday, October 13 at 8:15pm.

For more insights into this week's NFL predictions, check out the latest from the Dimers Sports Betting Podcast:

NFL straight up picks and predictions for Week 6

The NFL Week 6 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.